STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS‐Dependent PTEN/AKT1 Signaling

STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS‐Dependent PTEN/AKT1 Signaling

ABSTRACT Background Dysregulation of transcription factors is one of the most common factors for the pathogenesis of hepatocellular carcinoma (HCC). To the best of our knowledge, no study has yet investigated the clinical significance and functional role of STOX1 in HCC. Methods Real‐time PCR, Weste...

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Main Authors: Chunlin Jiang, Chong Wang, Jian Ao, Yangping Liu, Fengjie Sun, Wangpan Shi, Zeyi Guo, Yanping Wu, Luxiang Gan, Meimei Wu, Yaofeng Zhi, Zijie Meng, Wanting Wu, Juanhua Wu, Yong Ye, Xin Zhang, Dong Ren, Mingxin Pan
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Cancer Medicine
Subjects:
AKT1 signaling pathway
cell proliferation and cell cycle
hepatocellular carcinoma
reactive oxygen species
STOX1 isoform A
Online Access:https://doi.org/10.1002/cam4.70958
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