Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension

Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension

BACKGROUND Pulmonary arterial hypertension (PAH) is an incurable disease initiated by endothelial dysfunction, secondary to vascular inflammation and occlusive pulmonary arterial vascular remodeling, resulting in elevated pulmonary arterial pressure and right heart failure. Previous research has rep...

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Bibliographic Details
Main Authors: Xiao‐ting Tian, Zhou‐yang‐fan Peng, Yu‐si Wu, Yuan‐yuan Cao, Xue‐chun Li, Ying Li, Si‐Yuan Tang, Alex F. Chen, Xiao‐hui Li
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
BMPR2
GSDME
NLRP3
pulmonary arterial hypertension
pyroptosis
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.034726
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