From imaging to computational domains for physics-driven molecular biology simulations: Hindered diffusion in platelet masses.

When formed in vivo, murine hemostatic thrombi exhibit a heterogeneous architecture comprised of distinct regions of densely and sparsely packed platelets. In this study, we utilize high-resolution electron microscopy alongside machine learning and physics-based simulations to investigate how such c...

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Bibliographic Details
Main Authors: Catherine House, Ziyi Huang, Kaushik N Shankar, Sandra J Young, Meghan E Roberts, Scott L Diamond, Maurizio Tomaiuolo, Timothy J Stalker, Lu Lu, Talid Sinno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1012853
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