The hydroethanolic extract of leaves of Laelia furfuracea inhibits blood coagulation and platelet aggregation
Background: Laelia furfuracea is an orchid with anticoagulant properties; however, it is unknown which coagulation factors are inhibited and whether the plant has antiplatelet activity. Questions: Does the hydroethanolic extract of leaves of L. furfuracea inhibit coagulation factor activity and p...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedad Botánica de México, A. C.
2025-06-01
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| Series: | Botanical Sciences |
| Subjects: | |
| Online Access: | https://botanicalsciences.com.mx/index.php/botanicalSciences/article/view/3645 |
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| Summary: | Background: Laelia furfuracea is an orchid with anticoagulant properties; however, it is unknown which coagulation factors are inhibited and whether the plant has antiplatelet activity.
Questions: Does the hydroethanolic extract of leaves of L. furfuracea inhibit coagulation factor activity and platelet aggregation?
Studied species: Laelia furfuracea.
Study site and dates: Plant material was collected in April 2023 in Santo Domingo Yanhuitlán, Oaxaca, Mexico.
Methods: The anticoagulant and antiplatelet effects of the extracts of L. furfuracea were evaluated in samples from patients with thrombosis through coagulometric assays and light transmission aggregometry.
Results: The extract of L. furfuracea inhibited the activity of factors II, V, VIII, and XI in a concentration-dependent manner. The highest extract concentration, 14.0 mg/mL, inhibited about 60 % of factors II and V activity, but ˃ 95 % of factors VIII and XI. Moreover, at a 1.0 mg/mL concentration, the extract inhibited platelet aggregation induced by ADP, thrombin, and epinephrine in 85, 97, and 83 %, respectively.
Conclusions: It was demonstrated that the orchid extract inhibits both the activity of factors II, V, VIII, XI, and thrombin-, ADP-, and epinephrine-induced platelet aggregation. Polyphenols stand out among the possible bioactive compounds of the orchid with anticoagulant and/or antiplatelet activity.
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| ISSN: | 2007-4298 2007-4476 |