Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis

Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis

AimInsulin resistance (IR) is a hazard to human health in which peripheral insulin-target organs, like the liver, become less sensitive to normal levels of insulin. Dexamethasone (DEX)-induced IR is a distinct model of IR. Hence, the present study investigates the efficacy of mangiferin (Mang) in th...

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Bibliographic Details
Main Authors: Abdullah Q. Alsaedi, Manar A. Nader, Dalia H. El-Kashef, Marwa E. Abdelmageed
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
mangiferin
dexamethasone
VCAM
IRS1/AKT
NLRP3/NF-κB/TNF-α
insulin resistance/Wistar rats
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1572758/full
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