Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus)
ABSTRACT: Uterine adenocarcinoma and lymphoma are among the most diagnosed neoplasms in rabbits. Melanomas have also been reported in rabbits; however, they occur less frequently. A domestic rabbit (Oryctolagus cuniculus) was referred to for veterinary care due to an increase in ocular volume. Ophth...
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Universidade Federal de Santa Maria
2025-08-01
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| Series: | Ciência Rural |
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| author | Ronaldo José Piccoli Vinicius Dahm Karim Cristhine Pase Montagnini Arthur Colombari Cheng Stacy Wu Amália Ferronato Crisan Smaniotto Anderson Luiz de Carvalho Aline de Marco Viott |
| author_facet | Ronaldo José Piccoli Vinicius Dahm Karim Cristhine Pase Montagnini Arthur Colombari Cheng Stacy Wu Amália Ferronato Crisan Smaniotto Anderson Luiz de Carvalho Aline de Marco Viott |
| author_sort | Ronaldo José Piccoli |
| collection | DOAJ |
| description | ABSTRACT: Uterine adenocarcinoma and lymphoma are among the most diagnosed neoplasms in rabbits. Melanomas have also been reported in rabbits; however, they occur less frequently. A domestic rabbit (Oryctolagus cuniculus) was referred to for veterinary care due to an increase in ocular volume. Ophthalmic evaluation revealed buphthalmos of the left eye, conjunctivitis, corneal neovascularization, superficial ulcerative keratitis, and the presence of an intraocular mass. The patient underwent an enucleation procedure, and the ocular bulb was sent for histopathological evaluation. Five days after the surgery, the patient died and was sent for postmortem examination. Macroscopic examination of the ocular bulb revealed a firm whitish mass in the choroid in the uveal region upon sectioning. In the lungs, whitish, firm, multifocal to coalescent nodules, randomly distributed, were observed, measuring approximately 6 mm in diameter. Histological evaluation of the ocular bulb revealed a mesenchymal neoplastic proliferation, highly cellular, non-limited, non-encapsulated, with invasive growth. In the lung, a dense neoplastic proliferation of elongated and sometimes round cells was observed, densely cellular, poorly demarcated, infiltrative, and non-encapsulated appearance. Sections were subjected to Fontana Masson staining and immunohistochemical examination with the Melan-A antibody, showing positive staining. Based on microscopic, histochemical, and immunohistochemical characteristics, the diagnosis was intraocular amelanotic melanoma with metastasis to the lung. |
| format | Article |
| id | doaj-art-5058b7ca5a9643a7a006e909ced56998 |
| institution | Kabale University |
| issn | 1678-4596 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj-art-5058b7ca5a9643a7a006e909ced569982025-08-20T04:02:32ZengUniversidade Federal de Santa MariaCiência Rural1678-45962025-08-0155910.1590/0103-8478cr20240517Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus)Ronaldo José Piccolihttps://orcid.org/0000-0001-7741-8999Vinicius Dahmhttps://orcid.org/0000-0003-2873-1086Karim Cristhine Pase Montagninihttps://orcid.org/0000-0002-6239-8523Arthur Colombari Chenghttps://orcid.org/0000-0002-7490-3355Stacy Wuhttps://orcid.org/0000-0001-9934-5110Amália Ferronatohttps://orcid.org/0000-0003-1406-3734Crisan Smaniottohttps://orcid.org/0000-0002-5842-9008Anderson Luiz de Carvalhohttps://orcid.org/0000-0003-1926-0497Aline de Marco Viotthttps://orcid.org/0000-0003-1097-2359ABSTRACT: Uterine adenocarcinoma and lymphoma are among the most diagnosed neoplasms in rabbits. Melanomas have also been reported in rabbits; however, they occur less frequently. A domestic rabbit (Oryctolagus cuniculus) was referred to for veterinary care due to an increase in ocular volume. Ophthalmic evaluation revealed buphthalmos of the left eye, conjunctivitis, corneal neovascularization, superficial ulcerative keratitis, and the presence of an intraocular mass. The patient underwent an enucleation procedure, and the ocular bulb was sent for histopathological evaluation. Five days after the surgery, the patient died and was sent for postmortem examination. Macroscopic examination of the ocular bulb revealed a firm whitish mass in the choroid in the uveal region upon sectioning. In the lungs, whitish, firm, multifocal to coalescent nodules, randomly distributed, were observed, measuring approximately 6 mm in diameter. Histological evaluation of the ocular bulb revealed a mesenchymal neoplastic proliferation, highly cellular, non-limited, non-encapsulated, with invasive growth. In the lung, a dense neoplastic proliferation of elongated and sometimes round cells was observed, densely cellular, poorly demarcated, infiltrative, and non-encapsulated appearance. Sections were subjected to Fontana Masson staining and immunohistochemical examination with the Melan-A antibody, showing positive staining. Based on microscopic, histochemical, and immunohistochemical characteristics, the diagnosis was intraocular amelanotic melanoma with metastasis to the lung.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782025000900552&lng=en&tlng=enneoplasmmelaninoncologyophthalmologylagomorphs |
| spellingShingle | Ronaldo José Piccoli Vinicius Dahm Karim Cristhine Pase Montagnini Arthur Colombari Cheng Stacy Wu Amália Ferronato Crisan Smaniotto Anderson Luiz de Carvalho Aline de Marco Viott Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus) Ciência Rural neoplasm melanin oncology ophthalmology lagomorphs |
| title | Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus) |
| title_full | Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus) |
| title_fullStr | Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus) |
| title_full_unstemmed | Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus) |
| title_short | Amelanotic ocular melanoma with lung metastasis in a domestic rabbit (Oryctolagus cuniculus) |
| title_sort | amelanotic ocular melanoma with lung metastasis in a domestic rabbit oryctolagus cuniculus |
| topic | neoplasm melanin oncology ophthalmology lagomorphs |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782025000900552&lng=en&tlng=en |
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