Advancements in N-heterocyclic carbenes (NHCs) catalysis for benzoin reactions: A comprehensive review from past to present
N-heterocyclic carbenes (NHCs) catalyze benzoin condensation, which is a unique carbon-carbon bond-forming reaction. It entails a coupling reaction between two aldehydes catalyzed by NHCs that produce a-hydroxycarbonyl compounds (acyloins). NHCs have emerged as a potent class of organocatalysts, cat...
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| Format: | Article |
| Language: | English |
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Ural Federal University
2023-07-01
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| Series: | Chimica Techno Acta |
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| Online Access: | https://chimicatechnoacta.ru/article/view/6856 |
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| author | Pakin Noppawan Baramee Phungpis Kanokkan Worawut |
| author_facet | Pakin Noppawan Baramee Phungpis Kanokkan Worawut |
| author_sort | Pakin Noppawan |
| collection | DOAJ |
| description | N-heterocyclic carbenes (NHCs) catalyze benzoin condensation, which is a unique carbon-carbon bond-forming reaction. It entails a coupling reaction between two aldehydes catalyzed by NHCs that produce a-hydroxycarbonyl compounds (acyloins). NHCs have emerged as a potent class of organocatalysts, catalyzing numerous benzoin and benzoin-type reactions. This review provides an overview of the historical development of NHCs and their application in benzoin reactions. Additionally, recent advancements in NHC catalysis, including the use of chiral NHCs, are discussed. This review aims to provide a comprehensive understanding of the current state of NHC catalysis for benzoin reactions and its potential for future developments in synthetic chemistry. |
| format | Article |
| id | doaj-art-505328aad5044d7eb96fa02ae920d35d |
| institution | OA Journals |
| issn | 2411-1414 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Ural Federal University |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj-art-505328aad5044d7eb96fa02ae920d35d2025-08-20T02:05:17ZengUral Federal UniversityChimica Techno Acta2411-14142023-07-0110210.15826/chimtech.2023.10.2.144925Advancements in N-heterocyclic carbenes (NHCs) catalysis for benzoin reactions: A comprehensive review from past to presentPakin Noppawan0Baramee Phungpis1Kanokkan Worawut2Department of Chemistry, Faculty of Science, Mahasarakham UniversityFaculty of Natural Resources Rajamangala University of Technology Isan, Sakonnakhon CampusFaculty of Natural Resources Rajamangala University of Technology Isan, Sakonnakhon CampusN-heterocyclic carbenes (NHCs) catalyze benzoin condensation, which is a unique carbon-carbon bond-forming reaction. It entails a coupling reaction between two aldehydes catalyzed by NHCs that produce a-hydroxycarbonyl compounds (acyloins). NHCs have emerged as a potent class of organocatalysts, catalyzing numerous benzoin and benzoin-type reactions. This review provides an overview of the historical development of NHCs and their application in benzoin reactions. Additionally, recent advancements in NHC catalysis, including the use of chiral NHCs, are discussed. This review aims to provide a comprehensive understanding of the current state of NHC catalysis for benzoin reactions and its potential for future developments in synthetic chemistry.https://chimicatechnoacta.ru/article/view/6856acyloina-aminocarbonyl compoundbenzoin condensation a-hydroxycarbonyl compoundn-heterocyclic carbeneorganocatalysis |
| spellingShingle | Pakin Noppawan Baramee Phungpis Kanokkan Worawut Advancements in N-heterocyclic carbenes (NHCs) catalysis for benzoin reactions: A comprehensive review from past to present Chimica Techno Acta acyloin a-aminocarbonyl compound benzoin condensation a-hydroxycarbonyl compound n-heterocyclic carbene organocatalysis |
| title | Advancements in N-heterocyclic carbenes (NHCs) catalysis for benzoin reactions: A comprehensive review from past to present |
| title_full | Advancements in N-heterocyclic carbenes (NHCs) catalysis for benzoin reactions: A comprehensive review from past to present |
| title_fullStr | Advancements in N-heterocyclic carbenes (NHCs) catalysis for benzoin reactions: A comprehensive review from past to present |
| title_full_unstemmed | Advancements in N-heterocyclic carbenes (NHCs) catalysis for benzoin reactions: A comprehensive review from past to present |
| title_short | Advancements in N-heterocyclic carbenes (NHCs) catalysis for benzoin reactions: A comprehensive review from past to present |
| title_sort | advancements in n heterocyclic carbenes nhcs catalysis for benzoin reactions a comprehensive review from past to present |
| topic | acyloin a-aminocarbonyl compound benzoin condensation a-hydroxycarbonyl compound n-heterocyclic carbene organocatalysis |
| url | https://chimicatechnoacta.ru/article/view/6856 |
| work_keys_str_mv | AT pakinnoppawan advancementsinnheterocycliccarbenesnhcscatalysisforbenzoinreactionsacomprehensivereviewfrompasttopresent AT barameephungpis advancementsinnheterocycliccarbenesnhcscatalysisforbenzoinreactionsacomprehensivereviewfrompasttopresent AT kanokkanworawut advancementsinnheterocycliccarbenesnhcscatalysisforbenzoinreactionsacomprehensivereviewfrompasttopresent |