Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary Leishmaniasis
Tegumentary leishmaniasis (TL) presents two main clinical forms: cutaneous (CL) and mucosal (ML) leishmaniasis affecting skin and nasopharyngeal mucosa. Due to parasite localization through disease stages, recruitment of T cells expressing chemokine receptors and their ligands will influence the gen...
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2025-04-01
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| author | Julia Pimentel M. Fernanda García Bustos Paula Ragone Jorge D. Marco Paola Barroso Andrea Cecilia Mesías Mercedes Basombrío María Occhionero Federico Ramos Susana Adriana Laucella Cecilia Pérez Brandán Cecilia Parodi |
| author_facet | Julia Pimentel M. Fernanda García Bustos Paula Ragone Jorge D. Marco Paola Barroso Andrea Cecilia Mesías Mercedes Basombrío María Occhionero Federico Ramos Susana Adriana Laucella Cecilia Pérez Brandán Cecilia Parodi |
| author_sort | Julia Pimentel |
| collection | DOAJ |
| description | Tegumentary leishmaniasis (TL) presents two main clinical forms: cutaneous (CL) and mucosal (ML) leishmaniasis affecting skin and nasopharyngeal mucosa. Due to parasite localization through disease stages, recruitment of T cells expressing chemokine receptors and their ligands will influence the generated host responses. The aim of this work was to characterize differential profiles of T cells expressing chemokine receptors and their plasma ligands by flow cytometry and ELISA. CL patients showed increased numbers of effector memory CD4<sup>+</sup> T cells expressing skin homing receptors (CLA, CCR4), with the reversion of this effector phenotype observed after achieving clinical recovery. Meanwhile, ML patients showed higher frequencies of effector memory/terminal effector CD4<sup>+</sup> and CD8<sup>+</sup> T cells expressing chemokine receptors directed to skin (CLA, CCR4, CCR10) and mucosal (CCR6) tissues. Additionally, we reported that plasma amounts of ligands (CCL17, CCL20) vary according to the clinical form of TL. Finally, we demonstrated the ability of <i>Leishmania</i> spp. to modulate chemokine production (CCL17) in vitro. This work highlights the effector T cell response directed to skin and mucosal tissues in TL, emphasizing the role of cytotoxic functions in ML. The studied chemokine receptors could contribute to predicting disease progression and guiding future studies targeting relevant receptors to diminish pathogenic effector functions. |
| format | Article |
| id | doaj-art-503230d19e98495a959dfac1a8f6cea2 |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-503230d19e98495a959dfac1a8f6cea22025-08-20T03:14:20ZengMDPI AGCells2073-44092025-04-0114860410.3390/cells14080604Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary LeishmaniasisJulia Pimentel0M. Fernanda García Bustos1Paula Ragone2Jorge D. Marco3Paola Barroso4Andrea Cecilia Mesías5Mercedes Basombrío6María Occhionero7Federico Ramos8Susana Adriana Laucella9Cecilia Pérez Brandán10Cecilia Parodi11Instituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto Nacional de Parasitología Dr. Mario Fatala Chaben, Departamento de Investigación, Buenos Aires C1282AFF, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaInstituto de Patología Experimental, CONICET/Universidad Nacional de Salta, Salta A4408FVY, ArgentinaTegumentary leishmaniasis (TL) presents two main clinical forms: cutaneous (CL) and mucosal (ML) leishmaniasis affecting skin and nasopharyngeal mucosa. Due to parasite localization through disease stages, recruitment of T cells expressing chemokine receptors and their ligands will influence the generated host responses. The aim of this work was to characterize differential profiles of T cells expressing chemokine receptors and their plasma ligands by flow cytometry and ELISA. CL patients showed increased numbers of effector memory CD4<sup>+</sup> T cells expressing skin homing receptors (CLA, CCR4), with the reversion of this effector phenotype observed after achieving clinical recovery. Meanwhile, ML patients showed higher frequencies of effector memory/terminal effector CD4<sup>+</sup> and CD8<sup>+</sup> T cells expressing chemokine receptors directed to skin (CLA, CCR4, CCR10) and mucosal (CCR6) tissues. Additionally, we reported that plasma amounts of ligands (CCL17, CCL20) vary according to the clinical form of TL. Finally, we demonstrated the ability of <i>Leishmania</i> spp. to modulate chemokine production (CCL17) in vitro. This work highlights the effector T cell response directed to skin and mucosal tissues in TL, emphasizing the role of cytotoxic functions in ML. The studied chemokine receptors could contribute to predicting disease progression and guiding future studies targeting relevant receptors to diminish pathogenic effector functions.https://www.mdpi.com/2073-4409/14/8/604tegumentary leishmaniasiscutaneous leishmaniasismucosal leishmaniasischemokine receptorsmemory T lymphocyteschemokines |
| spellingShingle | Julia Pimentel M. Fernanda García Bustos Paula Ragone Jorge D. Marco Paola Barroso Andrea Cecilia Mesías Mercedes Basombrío María Occhionero Federico Ramos Susana Adriana Laucella Cecilia Pérez Brandán Cecilia Parodi Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary Leishmaniasis Cells tegumentary leishmaniasis cutaneous leishmaniasis mucosal leishmaniasis chemokine receptors memory T lymphocytes chemokines |
| title | Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary Leishmaniasis |
| title_full | Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary Leishmaniasis |
| title_fullStr | Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary Leishmaniasis |
| title_full_unstemmed | Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary Leishmaniasis |
| title_short | Memory T Cell Subsets Expressing Tissue Homing Receptors and Chemokine Levels in Human Tegumentary Leishmaniasis |
| title_sort | memory t cell subsets expressing tissue homing receptors and chemokine levels in human tegumentary leishmaniasis |
| topic | tegumentary leishmaniasis cutaneous leishmaniasis mucosal leishmaniasis chemokine receptors memory T lymphocytes chemokines |
| url | https://www.mdpi.com/2073-4409/14/8/604 |
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