Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902)
Introduction A growing body of literature has demonstrated that cancer patients have a higher risk of suicide and cardiovascular mortality compared with the general population, especially immediately after a cancer diagnosis. Using data from the National Cancer Registry in Japan launched in January...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2019-07-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/7/e030681.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846159320025137152 |
|---|---|
| author | Tatsuo Akechi Yosuke Uchitomi Saki Harashima Maiko Fujimori Tomohiro Matsuda Kumiko Saika Takaaki Hasegawa Keisuke Inoue Kazuhiro Yoshiuchi Isao Miyashiro Yutaka J Matsuoka |
| author_facet | Tatsuo Akechi Yosuke Uchitomi Saki Harashima Maiko Fujimori Tomohiro Matsuda Kumiko Saika Takaaki Hasegawa Keisuke Inoue Kazuhiro Yoshiuchi Isao Miyashiro Yutaka J Matsuoka |
| author_sort | Tatsuo Akechi |
| collection | DOAJ |
| description | Introduction A growing body of literature has demonstrated that cancer patients have a higher risk of suicide and cardiovascular mortality compared with the general population, especially immediately after a cancer diagnosis. Using data from the National Cancer Registry in Japan launched in January 2016, we will conduct the first nationwide population-based study in Japan to compare incidence of death by suicide, other externally caused injuries (ECIs) and cardiovascular disease following a cancer diagnosis with that of the general population in Japan. We will also aim to identify the patient subgroups and time periods associated with particularly high risk.Methods and analysis Our study subjects will consist of cancer cases diagnosed between 1 January 2016 and 31 December 2016 in Japan and they will be observed until 31 December 2018. We will calculate standardised mortality ratios (SMRs) and excess absolute risks (EARs) for suicide, other ECIs and cardiovascular death compared with the general population in Japan, after adjustment for sex, age and prefecture. SMRs and EARs will be calculated separately in relation to a number of factors: sex; age at diagnosis; time since cancer diagnosis; prefecture of residence at diagnosis; primary tumour site; behaviour code of tumour; extension of tumour; whether definitive surgery of the primary site was performed; and presence/absence of multiple primary tumours.Ethics and dissemination The study protocol was approved by the institutional review board and ethics committee of the National Cancer Center Japan and Nagoya City University Graduate School of Medical Sciences. The findings will be disseminated through peer-reviewed publications and conference presentations.Trial registration number UMIN000035118; Pre-results. |
| format | Article |
| id | doaj-art-502f3c0726fb486d9411b63c2a948c15 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-502f3c0726fb486d9411b63c2a948c152024-11-23T09:50:07ZengBMJ Publishing GroupBMJ Open2044-60552019-07-019710.1136/bmjopen-2019-030681Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902)Tatsuo Akechi0Yosuke Uchitomi1Saki Harashima2Maiko Fujimori3Tomohiro Matsuda4Kumiko Saika5Takaaki Hasegawa6Keisuke Inoue7Kazuhiro Yoshiuchi8Isao Miyashiro9Yutaka J Matsuoka103 Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDivision of Survivorship Research, Institute for Cancer Control, National Cancer Center, Tokyo, Japan1 Division of Health Care Research, Behavioral Science and Survivorship Research Group, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, JapanDivision of Survivorship Research, Institute for Cancer Control, National Cancer Center, Tokyo, Japan4 Center for Cancer Registries, Center for Cancer Control and Information Services, National Cancer Center Japan, Tokyo, Japan4 Center for Cancer Registries, Center for Cancer Control and Information Services, National Cancer Center Japan, Tokyo, Japan5 Division of Psycho-Oncology and Palliative Care, Nagoya City University Hospital, Nagoya, Japan1 Division of Health Care Research, Behavioral Science and Survivorship Research Group, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, JapanDepartment of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanCancer Control Center, Osaka International Cancer Institute, Osaka, Japan23 Research and Development Division, Health Policy Bureau, Ministry of Health, Labour and Welfare, Tokyo, JapanIntroduction A growing body of literature has demonstrated that cancer patients have a higher risk of suicide and cardiovascular mortality compared with the general population, especially immediately after a cancer diagnosis. Using data from the National Cancer Registry in Japan launched in January 2016, we will conduct the first nationwide population-based study in Japan to compare incidence of death by suicide, other externally caused injuries (ECIs) and cardiovascular disease following a cancer diagnosis with that of the general population in Japan. We will also aim to identify the patient subgroups and time periods associated with particularly high risk.Methods and analysis Our study subjects will consist of cancer cases diagnosed between 1 January 2016 and 31 December 2016 in Japan and they will be observed until 31 December 2018. We will calculate standardised mortality ratios (SMRs) and excess absolute risks (EARs) for suicide, other ECIs and cardiovascular death compared with the general population in Japan, after adjustment for sex, age and prefecture. SMRs and EARs will be calculated separately in relation to a number of factors: sex; age at diagnosis; time since cancer diagnosis; prefecture of residence at diagnosis; primary tumour site; behaviour code of tumour; extension of tumour; whether definitive surgery of the primary site was performed; and presence/absence of multiple primary tumours.Ethics and dissemination The study protocol was approved by the institutional review board and ethics committee of the National Cancer Center Japan and Nagoya City University Graduate School of Medical Sciences. The findings will be disseminated through peer-reviewed publications and conference presentations.Trial registration number UMIN000035118; Pre-results.https://bmjopen.bmj.com/content/9/7/e030681.full |
| spellingShingle | Tatsuo Akechi Yosuke Uchitomi Saki Harashima Maiko Fujimori Tomohiro Matsuda Kumiko Saika Takaaki Hasegawa Keisuke Inoue Kazuhiro Yoshiuchi Isao Miyashiro Yutaka J Matsuoka Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902) BMJ Open |
| title | Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902) |
| title_full | Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902) |
| title_fullStr | Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902) |
| title_full_unstemmed | Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902) |
| title_short | Suicide, other externally caused injuries and cardiovascular death following a cancer diagnosis: study protocol for a nationwide population-based study in Japan (J-SUPPORT 1902) |
| title_sort | suicide other externally caused injuries and cardiovascular death following a cancer diagnosis study protocol for a nationwide population based study in japan j support 1902 |
| url | https://bmjopen.bmj.com/content/9/7/e030681.full |
| work_keys_str_mv | AT tatsuoakechi suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT yosukeuchitomi suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT sakiharashima suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT maikofujimori suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT tomohiromatsuda suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT kumikosaika suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT takaakihasegawa suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT keisukeinoue suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT kazuhiroyoshiuchi suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT isaomiyashiro suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 AT yutakajmatsuoka suicideotherexternallycausedinjuriesandcardiovasculardeathfollowingacancerdiagnosisstudyprotocolforanationwidepopulationbasedstudyinjapanjsupport1902 |