One in a Million: A Case Report of Stiff Person Syndrome
Stiff person syndrome (SPS) is a rare autoimmune disease caused by lack of inhibition to excitatory neurotransmitters in the central nervous system (CNS) leading to inappropriate motor unit firing. The pathophysiology is incompletely understood; however, high titers of antiglutamic acid decarboxylas...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2022/7741545 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549438345707520 |
|---|---|
| author | Ruchi Yadav Neeraj Abrol Sima Terebelo |
| author_facet | Ruchi Yadav Neeraj Abrol Sima Terebelo |
| author_sort | Ruchi Yadav |
| collection | DOAJ |
| description | Stiff person syndrome (SPS) is a rare autoimmune disease caused by lack of inhibition to excitatory neurotransmitters in the central nervous system (CNS) leading to inappropriate motor unit firing. The pathophysiology is incompletely understood; however, high titers of antiglutamic acid decarboxylase antibody (anti-GAD Ab) are strongly associated with this disease. We present a 50-year-old woman with a history of ongoing gait and balance issues for 5 years with multiple negative workups. She recently had an acute exacerbation which left her bedbound, unable to move her legs or turn from side to side. After a negative workup at an outside hospital, the patient was discharged to a subacute rehabilitation facility. She then presented to our institution due to worsening of her condition and was ultimately diagnosed with SPS which was successfully treated. We review the case presentation and treatment options in the context of a severe disabling disease presentation. |
| format | Article |
| id | doaj-art-5028f114df8840739df71d7e8b5cab10 |
| institution | Kabale University |
| issn | 2090-6897 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-5028f114df8840739df71d7e8b5cab102025-02-03T06:11:18ZengWileyCase Reports in Rheumatology2090-68972022-01-01202210.1155/2022/7741545One in a Million: A Case Report of Stiff Person SyndromeRuchi Yadav0Neeraj Abrol1Sima Terebelo2Department of MedicineDepartment of MedicineDivision of RheumatologyStiff person syndrome (SPS) is a rare autoimmune disease caused by lack of inhibition to excitatory neurotransmitters in the central nervous system (CNS) leading to inappropriate motor unit firing. The pathophysiology is incompletely understood; however, high titers of antiglutamic acid decarboxylase antibody (anti-GAD Ab) are strongly associated with this disease. We present a 50-year-old woman with a history of ongoing gait and balance issues for 5 years with multiple negative workups. She recently had an acute exacerbation which left her bedbound, unable to move her legs or turn from side to side. After a negative workup at an outside hospital, the patient was discharged to a subacute rehabilitation facility. She then presented to our institution due to worsening of her condition and was ultimately diagnosed with SPS which was successfully treated. We review the case presentation and treatment options in the context of a severe disabling disease presentation.http://dx.doi.org/10.1155/2022/7741545 |
| spellingShingle | Ruchi Yadav Neeraj Abrol Sima Terebelo One in a Million: A Case Report of Stiff Person Syndrome Case Reports in Rheumatology |
| title | One in a Million: A Case Report of Stiff Person Syndrome |
| title_full | One in a Million: A Case Report of Stiff Person Syndrome |
| title_fullStr | One in a Million: A Case Report of Stiff Person Syndrome |
| title_full_unstemmed | One in a Million: A Case Report of Stiff Person Syndrome |
| title_short | One in a Million: A Case Report of Stiff Person Syndrome |
| title_sort | one in a million a case report of stiff person syndrome |
| url | http://dx.doi.org/10.1155/2022/7741545 |
| work_keys_str_mv | AT ruchiyadav oneinamillionacasereportofstiffpersonsyndrome AT neerajabrol oneinamillionacasereportofstiffpersonsyndrome AT simaterebelo oneinamillionacasereportofstiffpersonsyndrome |