Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition

Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition

Abstract Background Chondrocyte homeostasis is vital for maintaining the extracellular matrix (ECM) and overall cartilage health. In osteoarthritis (OA), for example, oxidative stress resulting from redox imbalances can disrupt chondrocyte homeostasis, leading to cartilage degradation. Hydrogen pero...

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Bibliographic Details
Main Authors: Thais Mingatos de Toledo, Hellen Paula Valerio, Amanda Teixeira de Melo, Renata Nascimento Gomes, Thatiana Corrêa de Melo, Marcus Vinicius Buri, Marcelo Medina de Souza, Deivid Martins Santos, Hugo Vigerelli, Miryam Paola Alvarez-Flores, Giuseppe Palmisano, Ana Marisa Chudzinski-Tavassi
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
Chondrocytes
Oxidative stress
Proteomics
Secretome
Osteoarthritis
Online Access:https://doi.org/10.1186/s12964-025-02291-z
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