Artificial intelligence in inflammatory bowel disease endoscopy – a review of current evidence and a critical perspective on future challenges

Inflammatory bowel disease (IBD) is a chronic and relapsing immune-mediated condition with a rising global prevalence. Endoscopic diagnosis, monitoring and surveillance currently depend on individual endoscopists, introducing subjectivity, variability, delays and potential diagnostic discrepancies....

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Main Authors: Ilaria Lodola, Ferdinando D’Amico, Silvio Danese, Tommaso Lorenzo Parigi
Format: Article
Language:English
Published: SAGE Publishing 2025-07-01
Series:Therapeutic Advances in Gastroenterology
Online Access:https://doi.org/10.1177/17562848251350896
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author Ilaria Lodola
Ferdinando D’Amico
Silvio Danese
Tommaso Lorenzo Parigi
author_facet Ilaria Lodola
Ferdinando D’Amico
Silvio Danese
Tommaso Lorenzo Parigi
author_sort Ilaria Lodola
collection DOAJ
description Inflammatory bowel disease (IBD) is a chronic and relapsing immune-mediated condition with a rising global prevalence. Endoscopic diagnosis, monitoring and surveillance currently depend on individual endoscopists, introducing subjectivity, variability, delays and potential diagnostic discrepancies. Artificial intelligence (AI) is poised to transform these processes. To date, most AI applications have focused on ulcerative colitis (UC) severity assessment, demonstrating promising results in replicating human evaluation, standardizing severity evaluation and facilitating the application of more complex scoring systems. Research into AI for Crohn’s disease (CD) has lagged behind UC, due to challenges such as disease heterogeneity and transmural extension; nevertheless, significant progress has been made to automate capsule endoscopy readings for CD. Beyond the grading of disease severity, AI is also being explored for tasks such as identifying dysplastic lesions, differentiating IBD from other conditions, assessing intestinal barrier permeability, guiding treatment decisions and integrating data from multiple omics, though studies in these areas remain exploratory. This review examines the current landscape of AI applications in IBD endoscopy, summarizes key studies in the field and explores the future potential of AI in IBD care.
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spelling doaj-art-501b89d619d047508dc2ca4316f7f8912025-08-20T03:34:25ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482025-07-011810.1177/17562848251350896Artificial intelligence in inflammatory bowel disease endoscopy – a review of current evidence and a critical perspective on future challengesIlaria LodolaFerdinando D’AmicoSilvio DaneseTommaso Lorenzo ParigiInflammatory bowel disease (IBD) is a chronic and relapsing immune-mediated condition with a rising global prevalence. Endoscopic diagnosis, monitoring and surveillance currently depend on individual endoscopists, introducing subjectivity, variability, delays and potential diagnostic discrepancies. Artificial intelligence (AI) is poised to transform these processes. To date, most AI applications have focused on ulcerative colitis (UC) severity assessment, demonstrating promising results in replicating human evaluation, standardizing severity evaluation and facilitating the application of more complex scoring systems. Research into AI for Crohn’s disease (CD) has lagged behind UC, due to challenges such as disease heterogeneity and transmural extension; nevertheless, significant progress has been made to automate capsule endoscopy readings for CD. Beyond the grading of disease severity, AI is also being explored for tasks such as identifying dysplastic lesions, differentiating IBD from other conditions, assessing intestinal barrier permeability, guiding treatment decisions and integrating data from multiple omics, though studies in these areas remain exploratory. This review examines the current landscape of AI applications in IBD endoscopy, summarizes key studies in the field and explores the future potential of AI in IBD care.https://doi.org/10.1177/17562848251350896
spellingShingle Ilaria Lodola
Ferdinando D’Amico
Silvio Danese
Tommaso Lorenzo Parigi
Artificial intelligence in inflammatory bowel disease endoscopy – a review of current evidence and a critical perspective on future challenges
Therapeutic Advances in Gastroenterology
title Artificial intelligence in inflammatory bowel disease endoscopy – a review of current evidence and a critical perspective on future challenges
title_full Artificial intelligence in inflammatory bowel disease endoscopy – a review of current evidence and a critical perspective on future challenges
title_fullStr Artificial intelligence in inflammatory bowel disease endoscopy – a review of current evidence and a critical perspective on future challenges
title_full_unstemmed Artificial intelligence in inflammatory bowel disease endoscopy – a review of current evidence and a critical perspective on future challenges
title_short Artificial intelligence in inflammatory bowel disease endoscopy – a review of current evidence and a critical perspective on future challenges
title_sort artificial intelligence in inflammatory bowel disease endoscopy a review of current evidence and a critical perspective on future challenges
url https://doi.org/10.1177/17562848251350896
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