Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial
Abstract To explore a potential link between resistance exercise and the gut‐brain axis, this study examined the impact of resistance exercise on intestinal permeability, as indicated by lipopolysaccharide binding protein (LBP), and mood state in healthy adults. Sedentary participants (n = 20; 39.5 ...
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Wiley
2025-02-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70219 |
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| author | Emily Dow Mario I. Hernandez Carol S. Johnston |
| author_facet | Emily Dow Mario I. Hernandez Carol S. Johnston |
| author_sort | Emily Dow |
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| description | Abstract To explore a potential link between resistance exercise and the gut‐brain axis, this study examined the impact of resistance exercise on intestinal permeability, as indicated by lipopolysaccharide binding protein (LBP), and mood state in healthy adults. Sedentary participants (n = 20; 39.5 ± 12.1 y; 27.4 ± 5.3 kg/m2) were randomly assigned to the resistance exercise (REX) or wait‐listed control (CON) groups. REX participants strength trained 3× weekly (advancing from 45%–55% to 70%–80% 1RM for 3–4 sets over 8 weeks). Strength testing, evaluation of mood states, and collection of fasting blood occurred at baseline and weeks 4 and 8. At baseline, LBP concentrations were inversely correlated to all strength measures (r range: −0.48 to −0.57; p < 0.05). The gain in total strength [(split squat left + right)/2 + bench press] was 45% higher for REX versus CON participants (p = 0.019), and serum LBP concentrations fell 16% for REX participants and rose 9% in CON participants (p = 0.014). Mood was significantly improved by resistance training versus control (but this improvement was not related to changes in LBP; r = −0.001). These findings support a role for resistance exercise in improving mood state and intestinal barrier function, but more research is warranted to further explore the effects of resistance training on the gut‐brain axis. |
| format | Article |
| id | doaj-art-501b352c1bb64fcbab59f85dbe8f9001 |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-501b352c1bb64fcbab59f85dbe8f90012025-08-20T02:05:10ZengWileyPhysiological Reports2051-817X2025-02-01133n/an/a10.14814/phy2.70219Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trialEmily Dow0Mario I. Hernandez1Carol S. Johnston2College of Health Solutions Arizona State University Phoenix Arizona USACollege of Health Solutions Arizona State University Phoenix Arizona USACollege of Health Solutions Arizona State University Phoenix Arizona USAAbstract To explore a potential link between resistance exercise and the gut‐brain axis, this study examined the impact of resistance exercise on intestinal permeability, as indicated by lipopolysaccharide binding protein (LBP), and mood state in healthy adults. Sedentary participants (n = 20; 39.5 ± 12.1 y; 27.4 ± 5.3 kg/m2) were randomly assigned to the resistance exercise (REX) or wait‐listed control (CON) groups. REX participants strength trained 3× weekly (advancing from 45%–55% to 70%–80% 1RM for 3–4 sets over 8 weeks). Strength testing, evaluation of mood states, and collection of fasting blood occurred at baseline and weeks 4 and 8. At baseline, LBP concentrations were inversely correlated to all strength measures (r range: −0.48 to −0.57; p < 0.05). The gain in total strength [(split squat left + right)/2 + bench press] was 45% higher for REX versus CON participants (p = 0.019), and serum LBP concentrations fell 16% for REX participants and rose 9% in CON participants (p = 0.014). Mood was significantly improved by resistance training versus control (but this improvement was not related to changes in LBP; r = −0.001). These findings support a role for resistance exercise in improving mood state and intestinal barrier function, but more research is warranted to further explore the effects of resistance training on the gut‐brain axis.https://doi.org/10.14814/phy2.70219depressioninflammationintestinal permeabilitymental healthresistance trainingstrength training |
| spellingShingle | Emily Dow Mario I. Hernandez Carol S. Johnston Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial Physiological Reports depression inflammation intestinal permeability mental health resistance training strength training |
| title | Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial |
| title_full | Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial |
| title_fullStr | Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial |
| title_full_unstemmed | Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial |
| title_short | Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial |
| title_sort | eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults a randomized controlled trial |
| topic | depression inflammation intestinal permeability mental health resistance training strength training |
| url | https://doi.org/10.14814/phy2.70219 |
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