Inhibition of Wnt/β-catenin increases anti-tumor activity by synergizing with sorafenib in hepatocellular carcinoma

Inhibition of Wnt/β-catenin increases anti-tumor activity by synergizing with sorafenib in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) poses a major global health challenge owing to limited treatment efficacy and drug resistance to therapies such as the tyrosine kinase inhibitor (TKI) sorafenib. We utilized a microfluidic three-dimensional (3D) drug testing system to assess drug responses in...

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Main Authors: Yuchao He, Dongming Liu, Aomei Ling, Zhiqiang Han, Jinfang Cui, Jinghui Cheng, Yuanying Feng, Wei Liu, Wenchen Gong, Yuren Xia, Liwei Chen, Yi Luo, Yu Wang, Xiangdong Tian, Qiang Wu, Lu Chen, Hua Guo
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07789-5
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