MCT4 inhibition attenuates inflammatory response to Mycobacterium avium paratuberculosis infection and restores intestinal epithelial integrity in vitro

MCT4 inhibition attenuates inflammatory response to Mycobacterium avium paratuberculosis infection and restores intestinal epithelial integrity in vitro

IntroductionMycobacterium avium paratuberculosis (MAP) plays a significant role in Crohn’s disease (CD). Monocarboxylate transporter 4 (MCT4) is a proton-coupled symporter of lactate that facilitates the inflammatory shift in macrophages and increases their reliance on glycolysis. MCT4 is also invol...

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Bibliographic Details
Main Authors: Ala’ Alhendi, Saleh A. Naser
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
MCT4
Mycobacterium avium paratuberculosis (MAP)
TLR-2
Crohn’s disease (CD)
SERPINE1
tight junction
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1562100/full
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