VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis

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Main Authors: Yu Tang, Hongfei Cui, Hongjun Zhao, Hui Luo, Xiaoxia Zuo, Junjiao Wu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-09-01
Series:Genes and Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304225000297
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author Yu Tang
Hongfei Cui
Hongjun Zhao
Hui Luo
Xiaoxia Zuo
Junjiao Wu
author_facet Yu Tang
Hongfei Cui
Hongjun Zhao
Hui Luo
Xiaoxia Zuo
Junjiao Wu
author_sort Yu Tang
collection DOAJ
format Article
id doaj-art-5016d80dc3f64cac8c5d3d45208b7ab0
institution DOAJ
issn 2352-3042
language English
publishDate 2025-09-01
publisher KeAi Communications Co., Ltd.
record_format Article
series Genes and Diseases
spelling doaj-art-5016d80dc3f64cac8c5d3d45208b7ab02025-08-20T02:43:53ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-09-0112510154010.1016/j.gendis.2025.101540VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosisYu Tang0Hongfei Cui1Hongjun Zhao2Hui Luo3Xiaoxia Zuo4Junjiao Wu5Aging Research Center, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaAging Research Center, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Provincial Skin Immunization and Medical Center, Changsha, Hunan 410008, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Provincial Skin Immunization and Medical Center, Changsha, Hunan 410008, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Provincial Skin Immunization and Medical Center, Changsha, Hunan 410008, ChinaCorresponding author. Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Hunan Provincial Skin Immunization and Medical Center, Changsha, Hunan 410008, Chinahttp://www.sciencedirect.com/science/article/pii/S2352304225000297
spellingShingle Yu Tang
Hongfei Cui
Hongjun Zhao
Hui Luo
Xiaoxia Zuo
Junjiao Wu
VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis
Genes and Diseases
title VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis
title_full VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis
title_fullStr VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis
title_full_unstemmed VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis
title_short VEXAS syndrome caused by a UBA1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis
title_sort vexas syndrome caused by a uba1 mutation is complicated by recurrent infections leading to hemophagocytic lymphohistiocytosis
url http://www.sciencedirect.com/science/article/pii/S2352304225000297
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AT hongfeicui vexassyndromecausedbyauba1mutationiscomplicatedbyrecurrentinfectionsleadingtohemophagocyticlymphohistiocytosis
AT hongjunzhao vexassyndromecausedbyauba1mutationiscomplicatedbyrecurrentinfectionsleadingtohemophagocyticlymphohistiocytosis
AT huiluo vexassyndromecausedbyauba1mutationiscomplicatedbyrecurrentinfectionsleadingtohemophagocyticlymphohistiocytosis
AT xiaoxiazuo vexassyndromecausedbyauba1mutationiscomplicatedbyrecurrentinfectionsleadingtohemophagocyticlymphohistiocytosis
AT junjiaowu vexassyndromecausedbyauba1mutationiscomplicatedbyrecurrentinfectionsleadingtohemophagocyticlymphohistiocytosis