A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity
An 82-year-old female presented with multiple oral ulcers and malena for 1 week. Her laboratory tests revealed pancytopenia and acute renal failure. She had history of rheumatoid arthritis for which she was taking 7.5 mg methotrexate weekly and stage 4 chronic kidney disease from diabetic nephropath...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/9056086 |
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| _version_ | 1832552115695779840 |
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| author | Nasreen Shaikh Muhammad Sardar Rishi Raj Punit Jariwala |
| author_facet | Nasreen Shaikh Muhammad Sardar Rishi Raj Punit Jariwala |
| author_sort | Nasreen Shaikh |
| collection | DOAJ |
| description | An 82-year-old female presented with multiple oral ulcers and malena for 1 week. Her laboratory tests revealed pancytopenia and acute renal failure. She had history of rheumatoid arthritis for which she was taking 7.5 mg methotrexate weekly and stage 4 chronic kidney disease from diabetic nephropathy. During the hospital stay, she developed pneumonia and septic shock requiring norepinephrine and vasopressin. She underwent continuous venovenous hemodiafiltration. Leucovorin, filgrastim, and multiple packed red blood cell and platelet transfusions were given. She remained hypotensive and pancytopenic despite all interventions. She died on day 6 of hospital stay from acute hypoxic respiratory failure due to septic shock. |
| format | Article |
| id | doaj-art-50167c5ebe0c4c5ab2cd48f83bab30f7 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-50167c5ebe0c4c5ab2cd48f83bab30f72025-02-03T05:59:31ZengWileyCase Reports in Medicine1687-96271687-96352018-01-01201810.1155/2018/90560869056086A Rapidly Fatal Case of Low-Dose Methotrexate ToxicityNasreen Shaikh0Muhammad Sardar1Rishi Raj2Punit Jariwala3Department of Internal Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, NJ 07740, USADepartment of Internal Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, NJ 07740, USADepartment of Internal Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, NJ 07740, USADepartment of Internal Medicine, Monmouth Medical Center, 300 Second Avenue, Long Branch, NJ 07740, USAAn 82-year-old female presented with multiple oral ulcers and malena for 1 week. Her laboratory tests revealed pancytopenia and acute renal failure. She had history of rheumatoid arthritis for which she was taking 7.5 mg methotrexate weekly and stage 4 chronic kidney disease from diabetic nephropathy. During the hospital stay, she developed pneumonia and septic shock requiring norepinephrine and vasopressin. She underwent continuous venovenous hemodiafiltration. Leucovorin, filgrastim, and multiple packed red blood cell and platelet transfusions were given. She remained hypotensive and pancytopenic despite all interventions. She died on day 6 of hospital stay from acute hypoxic respiratory failure due to septic shock.http://dx.doi.org/10.1155/2018/9056086 |
| spellingShingle | Nasreen Shaikh Muhammad Sardar Rishi Raj Punit Jariwala A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity Case Reports in Medicine |
| title | A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity |
| title_full | A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity |
| title_fullStr | A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity |
| title_full_unstemmed | A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity |
| title_short | A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity |
| title_sort | rapidly fatal case of low dose methotrexate toxicity |
| url | http://dx.doi.org/10.1155/2018/9056086 |
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