Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice
Sea cucumber saponins have attracted more attention in recent years due to biological activities. It is a popular practice to soak sea cucumber in Baijiu at home and being applied to industrial manufacturing in China. However, knowledge of the effect of alcohol on the absorption and metabolism of se...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001106 |
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| author | Wenxian Dang Rong Li Jinyue Yang Changhu Xue Qingrong Huang Yuming Wang Tiantian Zhang |
| author_facet | Wenxian Dang Rong Li Jinyue Yang Changhu Xue Qingrong Huang Yuming Wang Tiantian Zhang |
| author_sort | Wenxian Dang |
| collection | DOAJ |
| description | Sea cucumber saponins have attracted more attention in recent years due to biological activities. It is a popular practice to soak sea cucumber in Baijiu at home and being applied to industrial manufacturing in China. However, knowledge of the effect of alcohol on the absorption and metabolism of sea cucumber saponins is limited. The effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in BALB/c mice were investigated after gavage and tail intravenous injection. The results showed that the content of saponins in serum and liver was significantly higher under the influence of alcohol than that in the control group after oral administration. Alcohol promoted the absorption of sea cucumber saponins prototype as well as inhibited the process of saponins being transformed into deglycositic metabolites in the small intestine. Moreover, sea cucumber saponins remained in circulation for a long time and alcohol slowed down the clearance of sea cucumber saponins under the influence of alcohol after intravenous injection. This confirmed the feasibility of marinating sea cucumber in Baijiu to improve the efficacy of saponins and provides an important theoretical basis for the utilization of sea cucumber and the development of sea cucumber liquor. |
| format | Article |
| id | doaj-art-5012ff2332d04db29ac7a123009c7dfc |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-5012ff2332d04db29ac7a123009c7dfc2025-02-03T02:51:42ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-01131137145Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy miceWenxian Dang0Rong Li1Jinyue Yang2Changhu Xue3Qingrong Huang4Yuming Wang5Tiantian Zhang6College of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Department of Food Science, Rutgers State University, New Brunswick, NJ 08901, USACollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China; Corresponding author.College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China; Corresponding author.Sea cucumber saponins have attracted more attention in recent years due to biological activities. It is a popular practice to soak sea cucumber in Baijiu at home and being applied to industrial manufacturing in China. However, knowledge of the effect of alcohol on the absorption and metabolism of sea cucumber saponins is limited. The effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in BALB/c mice were investigated after gavage and tail intravenous injection. The results showed that the content of saponins in serum and liver was significantly higher under the influence of alcohol than that in the control group after oral administration. Alcohol promoted the absorption of sea cucumber saponins prototype as well as inhibited the process of saponins being transformed into deglycositic metabolites in the small intestine. Moreover, sea cucumber saponins remained in circulation for a long time and alcohol slowed down the clearance of sea cucumber saponins under the influence of alcohol after intravenous injection. This confirmed the feasibility of marinating sea cucumber in Baijiu to improve the efficacy of saponins and provides an important theoretical basis for the utilization of sea cucumber and the development of sea cucumber liquor.http://www.sciencedirect.com/science/article/pii/S2213453023001106Holothurin AEchinoside AAlcoholAbsorptionMetabolism |
| spellingShingle | Wenxian Dang Rong Li Jinyue Yang Changhu Xue Qingrong Huang Yuming Wang Tiantian Zhang Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice Food Science and Human Wellness Holothurin A Echinoside A Alcohol Absorption Metabolism |
| title | Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice |
| title_full | Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice |
| title_fullStr | Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice |
| title_full_unstemmed | Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice |
| title_short | Effects of alcohol on digestion, absorption and metabolism of sea cucumber saponins in healthy mice |
| title_sort | effects of alcohol on digestion absorption and metabolism of sea cucumber saponins in healthy mice |
| topic | Holothurin A Echinoside A Alcohol Absorption Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001106 |
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