Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications
Current treatment options for Alzheimer’s disease target neurotransmitters following the disease onset, and they offer limited efficacy without slowing down the disease progression. There has been an increasing concern in recent years targeting the histamine H3 receptor (H3R) in treating cognitive d...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2813-2998/4/2/22 |
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| author | Nagaraju Bandaru Sarad Pawar Naik Bukke Veera Mani Deepika Pedapati Gurugubelli Sowjanaya Vangmai Swaroopa Suggu Swathi Nalla Prashik Bhimrao Dudhe Joseph Obiezu Chukwujekwu Ezeonwumelu Abdullateef Isiaka Alagbonsi Hope Onohuean |
| author_facet | Nagaraju Bandaru Sarad Pawar Naik Bukke Veera Mani Deepika Pedapati Gurugubelli Sowjanaya Vangmai Swaroopa Suggu Swathi Nalla Prashik Bhimrao Dudhe Joseph Obiezu Chukwujekwu Ezeonwumelu Abdullateef Isiaka Alagbonsi Hope Onohuean |
| author_sort | Nagaraju Bandaru |
| collection | DOAJ |
| description | Current treatment options for Alzheimer’s disease target neurotransmitters following the disease onset, and they offer limited efficacy without slowing down the disease progression. There has been an increasing concern in recent years targeting the histamine H3 receptor (H3R) in treating cognitive disorders, including dementia. Preclinical studies have shown that antagonists of H3R or inverse agonists enhance the cognitive function in animal models with dementia by increasing the release of neurotransmitters associated with learning and memory. This review employed a systematic literature search across databases including PubMed, Scopus, Google Scholar, and ClinicalTrials.gov, selecting peer-reviewed studies. The results of this study illustrate the complex landscape of research on H3R modulators in dementia, highlighting both promising findings and ongoing challenges in translating preclinical discoveries into effective clinical interventions. Knowing the role of H3R in dementia and developing novel pharmacological interventions targeting these receptors represent a promising avenue for future research, leading to the development of new treatments for this devastating condition. |
| format | Article |
| id | doaj-art-50129a874a9b4503b3a6761e1285589e |
| institution | Kabale University |
| issn | 2813-2998 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Drugs and Drug Candidates |
| spelling | doaj-art-50129a874a9b4503b3a6761e1285589e2025-08-20T03:27:15ZengMDPI AGDrugs and Drug Candidates2813-29982025-05-01422210.3390/ddc4020022Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their ImplicationsNagaraju Bandaru0Sarad Pawar Naik Bukke1Veera Mani Deepika Pedapati2Gurugubelli Sowjanaya3Vangmai Swaroopa Suggu4Swathi Nalla5Prashik Bhimrao Dudhe6Joseph Obiezu Chukwujekwu Ezeonwumelu7Abdullateef Isiaka Alagbonsi8Hope Onohuean9School of Pharmaceutical Sciences (SOPS), Sandip University, Nasik 422213, IndiaDepartment of Pharmaceutics and Pharmaceutical Technology, Kampala International University, Western Campus, Ishaka-Bushenyi P.O. Box 20000, UgandaDepartment of Pharmacy Practice, Aditya Pharmacy College, Surampalem, Kakinada 533437, IndiaDepartment of Pharmacy Practice, Aditya Pharmacy College, Surampalem, Kakinada 533437, IndiaDepartment of Pharmacy Practice, Aditya Pharmacy College, Surampalem, Kakinada 533437, IndiaDepartment of Pharmacology, Malla Reddy Pharmacy College, Maisammaguda, Hyderabad 500014, IndiaSchool of Pharmaceutical Sciences (SOPS), Sandip University, Nasik 422213, IndiaDepartment of Clinical Pharmacy and Pharmacy Practice, Kampala International University, Western Campus, Ishaka-Bushenyi P.O. Box 20000, UgandaDepartment of Physiology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Butare, RwandaMetagenomics, Endocrine, and Tropical Disease Research Group (BMETDREG), Kampala International University, Western Campus, Ishaka-Bushenyi P.O. Box 20000, UgandaCurrent treatment options for Alzheimer’s disease target neurotransmitters following the disease onset, and they offer limited efficacy without slowing down the disease progression. There has been an increasing concern in recent years targeting the histamine H3 receptor (H3R) in treating cognitive disorders, including dementia. Preclinical studies have shown that antagonists of H3R or inverse agonists enhance the cognitive function in animal models with dementia by increasing the release of neurotransmitters associated with learning and memory. This review employed a systematic literature search across databases including PubMed, Scopus, Google Scholar, and ClinicalTrials.gov, selecting peer-reviewed studies. The results of this study illustrate the complex landscape of research on H3R modulators in dementia, highlighting both promising findings and ongoing challenges in translating preclinical discoveries into effective clinical interventions. Knowing the role of H3R in dementia and developing novel pharmacological interventions targeting these receptors represent a promising avenue for future research, leading to the development of new treatments for this devastating condition.https://www.mdpi.com/2813-2998/4/2/22benchbedsidehistaminereceptorsmodulatorsfindings |
| spellingShingle | Nagaraju Bandaru Sarad Pawar Naik Bukke Veera Mani Deepika Pedapati Gurugubelli Sowjanaya Vangmai Swaroopa Suggu Swathi Nalla Prashik Bhimrao Dudhe Joseph Obiezu Chukwujekwu Ezeonwumelu Abdullateef Isiaka Alagbonsi Hope Onohuean Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications Drugs and Drug Candidates bench bedside histamine receptors modulators findings |
| title | Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications |
| title_full | Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications |
| title_fullStr | Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications |
| title_full_unstemmed | Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications |
| title_short | Pathophysiology of Alzheimer’s Disease: Focus on H3 Receptor Modulators and Their Implications |
| title_sort | pathophysiology of alzheimer s disease focus on h3 receptor modulators and their implications |
| topic | bench bedside histamine receptors modulators findings |
| url | https://www.mdpi.com/2813-2998/4/2/22 |
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