GALECTIN-3 AND NT-proBNP AS BIOMARKERS OF HEART FAILURE DECOMPENSATION
Aim. To compare the levels of galectin-3 and N-terminal brain natriuretic peptide precursor (NT-proBNP) in heart failure patients with saved ejection fraction of the left ventricle (HF-sEF) and heart failure with low ejection fraction (HF-lEF). To study the possibilities for implementation of galect...
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«FIRMA «SILICEA» LLC
2017-02-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/829 |
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| author | Yu. V. Dubolazova O. M. Drapkina |
| author_facet | Yu. V. Dubolazova O. M. Drapkina |
| author_sort | Yu. V. Dubolazova |
| collection | DOAJ |
| description | Aim. To compare the levels of galectin-3 and N-terminal brain natriuretic peptide precursor (NT-proBNP) in heart failure patients with saved ejection fraction of the left ventricle (HF-sEF) and heart failure with low ejection fraction (HF-lEF). To study the possibilities for implementation of galectin-3 and NT-proBNP as markers of HF decompensation in HF-sEFMaterial and methods. Totally, 30 patients with HF-sEF included (17 females, 13 males, mean age 65±8 y.o.) and 30 patients with HF-lEF (11 females, 19 males, mean age 63±11 y.o.). All patients underwent physical examination, 6-minute walking test, clinical condition assessment by clinical condition score (CCS), echocardiography (Echo), tissue doppler imaging, measurement of galectin-3 and NT-proBNP levels at admission.Results. The difference of mean levels of NT-proBNP in HF-sEF and HF-lEF did not differ significantly (153,23±114,44 fM/ml and 142,45±90,82 fM/ml, resp., t=0,4, p=0,68). A direct correlation was found for HF clinics in both groups (r=0,46, p<0,05, 95% CI). In HF-sEF the negative correlation was found for the mean level of NT-proBNP and 6-minute walking test results by CCS, direct correlation between clinical condition of patients by CCS (r=0,048, p=0,02, 95% CI), direct correlation of clinical presentation and real systolic pressure in in pulmonary artery (r=0,4, p=0,03, 95% CI); negative correlation of the mean NT-proBNP and peak A velocity (r=-0,52, p=0,003, 95% CI). Mean level of galectin-3 in blood plasma in HF-sEF (0,98±1,93 hg/mL) is significantly higher than in HF-lEF (0,13±0,07 ng/mL) (t=2,41, p=0,01). There was no relation found for the main clinical presentation of HF and galectin-3 level in HF patients. In both groups there was no relation between the mean galectin-3 level and 6-minute test, and clinical condition by CCS. There was positive relation of ejection fraction of the left ventricle by Echo and mean level of galectin-3 (r=0,45, p=0,012, 95% CI).Conclusion. The level of NT-proBNP does not differ in HF-sEF and HF-lEF patients and is related to the severity of CHF. Therefore, NT-proBNP might be used as a marker of CHF decompensation. Level of galecton-3 is significantly higher in HFsEF patients and does not relate on severity of CHF. Both markers can be used for diagnostics of CHF patients and to reveal HF-sEF before Echo is done. |
| format | Article |
| id | doaj-art-50127664bd054cfd897f0ce0c749ea39 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2017-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-50127664bd054cfd897f0ce0c749ea392025-08-20T03:57:26Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-02-01019510110.15829/1560-4071-2017-1-95-101783GALECTIN-3 AND NT-proBNP AS BIOMARKERS OF HEART FAILURE DECOMPENSATIONYu. V. Dubolazova0O. M. Drapkina1National Research Center for Preventive Medicine of the Ministry of HealthNational Research Center for Preventive Medicine of the Ministry of HealthAim. To compare the levels of galectin-3 and N-terminal brain natriuretic peptide precursor (NT-proBNP) in heart failure patients with saved ejection fraction of the left ventricle (HF-sEF) and heart failure with low ejection fraction (HF-lEF). To study the possibilities for implementation of galectin-3 and NT-proBNP as markers of HF decompensation in HF-sEFMaterial and methods. Totally, 30 patients with HF-sEF included (17 females, 13 males, mean age 65±8 y.o.) and 30 patients with HF-lEF (11 females, 19 males, mean age 63±11 y.o.). All patients underwent physical examination, 6-minute walking test, clinical condition assessment by clinical condition score (CCS), echocardiography (Echo), tissue doppler imaging, measurement of galectin-3 and NT-proBNP levels at admission.Results. The difference of mean levels of NT-proBNP in HF-sEF and HF-lEF did not differ significantly (153,23±114,44 fM/ml and 142,45±90,82 fM/ml, resp., t=0,4, p=0,68). A direct correlation was found for HF clinics in both groups (r=0,46, p<0,05, 95% CI). In HF-sEF the negative correlation was found for the mean level of NT-proBNP and 6-minute walking test results by CCS, direct correlation between clinical condition of patients by CCS (r=0,048, p=0,02, 95% CI), direct correlation of clinical presentation and real systolic pressure in in pulmonary artery (r=0,4, p=0,03, 95% CI); negative correlation of the mean NT-proBNP and peak A velocity (r=-0,52, p=0,003, 95% CI). Mean level of galectin-3 in blood plasma in HF-sEF (0,98±1,93 hg/mL) is significantly higher than in HF-lEF (0,13±0,07 ng/mL) (t=2,41, p=0,01). There was no relation found for the main clinical presentation of HF and galectin-3 level in HF patients. In both groups there was no relation between the mean galectin-3 level and 6-minute test, and clinical condition by CCS. There was positive relation of ejection fraction of the left ventricle by Echo and mean level of galectin-3 (r=0,45, p=0,012, 95% CI).Conclusion. The level of NT-proBNP does not differ in HF-sEF and HF-lEF patients and is related to the severity of CHF. Therefore, NT-proBNP might be used as a marker of CHF decompensation. Level of galecton-3 is significantly higher in HFsEF patients and does not relate on severity of CHF. Both markers can be used for diagnostics of CHF patients and to reveal HF-sEF before Echo is done.https://russjcardiol.elpub.ru/jour/article/view/829heart failure with normal ejection fractionnt-probnpgalectin-3biomarkers of heart failure |
| spellingShingle | Yu. V. Dubolazova O. M. Drapkina GALECTIN-3 AND NT-proBNP AS BIOMARKERS OF HEART FAILURE DECOMPENSATION Российский кардиологический журнал heart failure with normal ejection fraction nt-probnp galectin-3 biomarkers of heart failure |
| title | GALECTIN-3 AND NT-proBNP AS BIOMARKERS OF HEART FAILURE DECOMPENSATION |
| title_full | GALECTIN-3 AND NT-proBNP AS BIOMARKERS OF HEART FAILURE DECOMPENSATION |
| title_fullStr | GALECTIN-3 AND NT-proBNP AS BIOMARKERS OF HEART FAILURE DECOMPENSATION |
| title_full_unstemmed | GALECTIN-3 AND NT-proBNP AS BIOMARKERS OF HEART FAILURE DECOMPENSATION |
| title_short | GALECTIN-3 AND NT-proBNP AS BIOMARKERS OF HEART FAILURE DECOMPENSATION |
| title_sort | galectin 3 and nt probnp as biomarkers of heart failure decompensation |
| topic | heart failure with normal ejection fraction nt-probnp galectin-3 biomarkers of heart failure |
| url | https://russjcardiol.elpub.ru/jour/article/view/829 |
| work_keys_str_mv | AT yuvdubolazova galectin3andntprobnpasbiomarkersofheartfailuredecompensation AT omdrapkina galectin3andntprobnpasbiomarkersofheartfailuredecompensation |