Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women
The combination of thrombophilia and pregnancy increases the risk of thrombosis and the potential for adverse outcomes during pregnancy. The most significant common inherited risk factor for thrombophilia is activated protein C resistance (APCR), a poor anticoagulant response of APC in haemostasis,...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2011/232840 |
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| author | Sara Sedano-Balbás Mark Lyons Brendan Cleary Margaret Murray Geraldine Gaffney Majella Maher |
| author_facet | Sara Sedano-Balbás Mark Lyons Brendan Cleary Margaret Murray Geraldine Gaffney Majella Maher |
| author_sort | Sara Sedano-Balbás |
| collection | DOAJ |
| description | The combination of thrombophilia and pregnancy increases the risk of thrombosis and the potential for adverse outcomes during pregnancy. The most significant common inherited risk factor for thrombophilia is activated protein C resistance (APCR), a poor anticoagulant response of APC in haemostasis, which is mainly caused by an inherited single-nucleotide polymorphism (SNP), factor V G1691A (FV Leiden) (FVL), referred as inherited APCR. Changes in the levels of coagulation factors: FV, FVIII, and FIX, and anticoagulant factors: protein S (PS) and protein C (PC) can alter APC function causing acquired APCR. Prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T are prothrombotic SNPs which in association with APCR can also increase the risk of thrombosis amongst Caucasians. In this study, a correlation between an acquired APCR phenotype and increased levels of factors V, VIII, and IX was demonstrated. Thrombophilic mutations amongst our acquired APCR pregnant women cohort are relatively common but do not appear to exert a severe undue adverse effect on pregnancy. |
| format | Article |
| id | doaj-art-50112fe2f04942eebde5b0d3083bf65e |
| institution | OA Journals |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-50112fe2f04942eebde5b0d3083bf65e2025-08-20T02:05:17ZengWileyJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/232840232840Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant WomenSara Sedano-Balbás0Mark Lyons1Brendan Cleary2Margaret Murray3Geraldine Gaffney4Majella Maher5Molecular Diagnostics Research Group, National Centre for Biomedical Engineering Science, National University of Ireland, Galway, IrelandDepartment of Haematology, University College Hospital, Galway, IrelandDepartment of Haematology, University College Hospital, Galway, IrelandDepartment of Haematology, University College Hospital, Galway, IrelandDepartment of Obstetrics & Gynaecology, University College Hospital, Galway, IrelandMolecular Diagnostics Research Group, National Centre for Biomedical Engineering Science, National University of Ireland, Galway, IrelandThe combination of thrombophilia and pregnancy increases the risk of thrombosis and the potential for adverse outcomes during pregnancy. The most significant common inherited risk factor for thrombophilia is activated protein C resistance (APCR), a poor anticoagulant response of APC in haemostasis, which is mainly caused by an inherited single-nucleotide polymorphism (SNP), factor V G1691A (FV Leiden) (FVL), referred as inherited APCR. Changes in the levels of coagulation factors: FV, FVIII, and FIX, and anticoagulant factors: protein S (PS) and protein C (PC) can alter APC function causing acquired APCR. Prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T are prothrombotic SNPs which in association with APCR can also increase the risk of thrombosis amongst Caucasians. In this study, a correlation between an acquired APCR phenotype and increased levels of factors V, VIII, and IX was demonstrated. Thrombophilic mutations amongst our acquired APCR pregnant women cohort are relatively common but do not appear to exert a severe undue adverse effect on pregnancy.http://dx.doi.org/10.1155/2011/232840 |
| spellingShingle | Sara Sedano-Balbás Mark Lyons Brendan Cleary Margaret Murray Geraldine Gaffney Majella Maher Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women Journal of Pregnancy |
| title | Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women |
| title_full | Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women |
| title_fullStr | Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women |
| title_full_unstemmed | Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women |
| title_short | Acquired Activated Protein C Resistance, Thrombophilia and Adverse Pregnancy Outcomes: A Study Performed in an Irish Cohort of Pregnant Women |
| title_sort | acquired activated protein c resistance thrombophilia and adverse pregnancy outcomes a study performed in an irish cohort of pregnant women |
| url | http://dx.doi.org/10.1155/2011/232840 |
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