Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without Atypia
The purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m–pentavalent dimercaptosuccinic acid ( 99m Tc-(V)DMSA) in women with severe epithelial and atypical epithelial breast hyperplasia. Eight patients with...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2010-09-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2010.00028 |
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| author | Vassilios Papantoniou Angeliki Tsaroucha Pipitsa Valsamaki Spyridon Tsiouris Evangelia Sotiropoulou Theodore Karianos Spyridon Marinopoulos Athina Fothiadaki Maria Sotiropoulou Aikaterini Archontaki Konstantinos Syrgiannis Konstantinos Dimitrakakis Aris Antsaklis |
| author_facet | Vassilios Papantoniou Angeliki Tsaroucha Pipitsa Valsamaki Spyridon Tsiouris Evangelia Sotiropoulou Theodore Karianos Spyridon Marinopoulos Athina Fothiadaki Maria Sotiropoulou Aikaterini Archontaki Konstantinos Syrgiannis Konstantinos Dimitrakakis Aris Antsaklis |
| author_sort | Vassilios Papantoniou |
| collection | DOAJ |
| description | The purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m–pentavalent dimercaptosuccinic acid ( 99m Tc-(V)DMSA) in women with severe epithelial and atypical epithelial breast hyperplasia. Eight patients with histologically confirmed severe epithelial breast hyperplasia with ( n = 4) and without atypia ( n = 4) were submitted prospectively to 99m Tc-(V)DMSA scintimammography before and after a 4-week course of 400 mg ibuprofen daily oral intake. Lesion to background ratios 60 minutes postinjection were calculated and compared ( t -test) before and after ibuprofen administration. Prior to ibuprofen, the patients with severe epithelial hyperplasia displayed a significantly higher 99m Tc-(V)DMSA uptake ratio compared to those with atypical epithelial hyperplasia (2.40 ± 0.32 vs 1.67 ± 0.09, respectively; p = .003). They also exhibited a more substantial percent decline in tracer uptake postibuprofen compared to women with atypical epithelial hyperplasia (62.0 ± 7.1 vs 15.0 ± 0.2, respectively; p = .001). Ibuprofen induces significant uptake reduction of the proliferation-seeking radiotracer 99m Tc-(V)DMSA in severe epithelial breast hyperplasia without atypia. This agent could therefore constitute a potential imaging tool for monitoring chemoprophylaxis effectiveness in women at the early stages of malignant transformation. |
| format | Article |
| id | doaj-art-500ee44913a043d0adb9981a2a3ec39a |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2010-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-500ee44913a043d0adb9981a2a3ec39a2025-01-02T22:37:55ZengSAGE PublishingMolecular Imaging1536-01212010-09-01910.2310/7290.2010.0002810.2310_7290.2010.00028Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without AtypiaVassilios PapantoniouAngeliki TsarouchaPipitsa ValsamakiSpyridon TsiourisEvangelia SotiropoulouTheodore KarianosSpyridon MarinopoulosAthina FothiadakiMaria SotiropoulouAikaterini ArchontakiKonstantinos SyrgiannisKonstantinos DimitrakakisAris AntsaklisThe purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m–pentavalent dimercaptosuccinic acid ( 99m Tc-(V)DMSA) in women with severe epithelial and atypical epithelial breast hyperplasia. Eight patients with histologically confirmed severe epithelial breast hyperplasia with ( n = 4) and without atypia ( n = 4) were submitted prospectively to 99m Tc-(V)DMSA scintimammography before and after a 4-week course of 400 mg ibuprofen daily oral intake. Lesion to background ratios 60 minutes postinjection were calculated and compared ( t -test) before and after ibuprofen administration. Prior to ibuprofen, the patients with severe epithelial hyperplasia displayed a significantly higher 99m Tc-(V)DMSA uptake ratio compared to those with atypical epithelial hyperplasia (2.40 ± 0.32 vs 1.67 ± 0.09, respectively; p = .003). They also exhibited a more substantial percent decline in tracer uptake postibuprofen compared to women with atypical epithelial hyperplasia (62.0 ± 7.1 vs 15.0 ± 0.2, respectively; p = .001). Ibuprofen induces significant uptake reduction of the proliferation-seeking radiotracer 99m Tc-(V)DMSA in severe epithelial breast hyperplasia without atypia. This agent could therefore constitute a potential imaging tool for monitoring chemoprophylaxis effectiveness in women at the early stages of malignant transformation.https://doi.org/10.2310/7290.2010.00028 |
| spellingShingle | Vassilios Papantoniou Angeliki Tsaroucha Pipitsa Valsamaki Spyridon Tsiouris Evangelia Sotiropoulou Theodore Karianos Spyridon Marinopoulos Athina Fothiadaki Maria Sotiropoulou Aikaterini Archontaki Konstantinos Syrgiannis Konstantinos Dimitrakakis Aris Antsaklis Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without Atypia Molecular Imaging |
| title | Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without Atypia |
| title_full | Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without Atypia |
| title_fullStr | Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without Atypia |
| title_full_unstemmed | Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without Atypia |
| title_short | Ibuprofen Induces Reduction of the Proliferation-Seeking Radiotracer Tc-(V)DMSA Uptake in Severe Epithelial Breast Hyperplasia without Atypia |
| title_sort | ibuprofen induces reduction of the proliferation seeking radiotracer tc v dmsa uptake in severe epithelial breast hyperplasia without atypia |
| url | https://doi.org/10.2310/7290.2010.00028 |
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