Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study
BackgroundIdiopathic epilepsy is a major global health burden that causes premature death and disability. Previous studies have systematically analyzed trends in the burden of idiopathic epilepsy. However, analyses of the impact of social factors, health campaigns and policies on the burden of idiop...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1598497/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850237128944910336 |
|---|---|
| author | Xuewen Rong Dongting Yu Wei Zhao Jingyu Xiao Du Feng Gengfeng Chen Zemeng Cao Liming Shu |
| author_facet | Xuewen Rong Dongting Yu Wei Zhao Jingyu Xiao Du Feng Gengfeng Chen Zemeng Cao Liming Shu |
| author_sort | Xuewen Rong |
| collection | DOAJ |
| description | BackgroundIdiopathic epilepsy is a major global health burden that causes premature death and disability. Previous studies have systematically analyzed trends in the burden of idiopathic epilepsy. However, analyses of the impact of social factors, health campaigns and policies on the burden of idiopathic epilepsy are lacking. This study aims to fill that gap.MethodsWe used data from the 2021 Global Burden of Disease (GBD) and calculated the estimated annual percentage changes (EAPC) to assess trends. Decomposition analysis breaks down changes in the burden of idiopathic epilepsy into three factors. Correlation analysis measures the association between the EAPC and social development. Inequality analysis illustrates the disparity in the burden of idiopathic epilepsy among countries. Generalized difference-in-differences (GDID) and synthetic difference-in-differences (SDID) analyses are used to quantify the impact of health campaigns or policies on the burden of idiopathic epilepsy.ResultsWith respect to incidence, aging had a negative impact. The correlation between the sociodemographic index (SDI) and EAPC had a rho value of −0.18. The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.ConclusionThis study explores the impact of social factors and health campaigns on the burden of idiopathic epilepsy. We emphasize the need for targeted prevention and treatment strategies to effectively address the burden of idiopathic epilepsy. |
| format | Article |
| id | doaj-art-500e4a255ac846e083cc75cdfec31d6e |
| institution | OA Journals |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-500e4a255ac846e083cc75cdfec31d6e2025-08-20T02:01:49ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-06-011310.3389/fpubh.2025.15984971598497Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences studyXuewen Rong0Dongting Yu1Wei Zhao2Jingyu Xiao3Du Feng4Gengfeng Chen5Zemeng Cao6Liming Shu7Nanshan School, Guangzhou Medical University, Guangzhou, ChinaNanshan School, Guangzhou Medical University, Guangzhou, ChinaSchool of Pediatrics, Guangzhou Medical University, Guangzhou, ChinaNanshan School, Guangzhou Medical University, Guangzhou, ChinaNanshan School, Guangzhou Medical University, Guangzhou, ChinaNanshan School, Guangzhou Medical University, Guangzhou, ChinaNanshan School, Guangzhou Medical University, Guangzhou, ChinaDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaBackgroundIdiopathic epilepsy is a major global health burden that causes premature death and disability. Previous studies have systematically analyzed trends in the burden of idiopathic epilepsy. However, analyses of the impact of social factors, health campaigns and policies on the burden of idiopathic epilepsy are lacking. This study aims to fill that gap.MethodsWe used data from the 2021 Global Burden of Disease (GBD) and calculated the estimated annual percentage changes (EAPC) to assess trends. Decomposition analysis breaks down changes in the burden of idiopathic epilepsy into three factors. Correlation analysis measures the association between the EAPC and social development. Inequality analysis illustrates the disparity in the burden of idiopathic epilepsy among countries. Generalized difference-in-differences (GDID) and synthetic difference-in-differences (SDID) analyses are used to quantify the impact of health campaigns or policies on the burden of idiopathic epilepsy.ResultsWith respect to incidence, aging had a negative impact. The correlation between the sociodemographic index (SDI) and EAPC had a rho value of −0.18. The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.ConclusionThis study explores the impact of social factors and health campaigns on the burden of idiopathic epilepsy. We emphasize the need for targeted prevention and treatment strategies to effectively address the burden of idiopathic epilepsy.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1598497/fullidiopathic epilepsydisability-adjusted life yearsgeneralized difference-in-differencessynthetic difference-in-differencesinequalityglobal burden of disease |
| spellingShingle | Xuewen Rong Dongting Yu Wei Zhao Jingyu Xiao Du Feng Gengfeng Chen Zemeng Cao Liming Shu Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study Frontiers in Public Health idiopathic epilepsy disability-adjusted life years generalized difference-in-differences synthetic difference-in-differences inequality global burden of disease |
| title | Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study |
| title_full | Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study |
| title_fullStr | Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study |
| title_full_unstemmed | Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study |
| title_short | Impact of social factors and health campaigns on the burden of idiopathic epilepsy: an inequality, decomposition, generalized and synthetic difference-in-differences study |
| title_sort | impact of social factors and health campaigns on the burden of idiopathic epilepsy an inequality decomposition generalized and synthetic difference in differences study |
| topic | idiopathic epilepsy disability-adjusted life years generalized difference-in-differences synthetic difference-in-differences inequality global burden of disease |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1598497/full |
| work_keys_str_mv | AT xuewenrong impactofsocialfactorsandhealthcampaignsontheburdenofidiopathicepilepsyaninequalitydecompositiongeneralizedandsyntheticdifferenceindifferencesstudy AT dongtingyu impactofsocialfactorsandhealthcampaignsontheburdenofidiopathicepilepsyaninequalitydecompositiongeneralizedandsyntheticdifferenceindifferencesstudy AT weizhao impactofsocialfactorsandhealthcampaignsontheburdenofidiopathicepilepsyaninequalitydecompositiongeneralizedandsyntheticdifferenceindifferencesstudy AT jingyuxiao impactofsocialfactorsandhealthcampaignsontheburdenofidiopathicepilepsyaninequalitydecompositiongeneralizedandsyntheticdifferenceindifferencesstudy AT dufeng impactofsocialfactorsandhealthcampaignsontheburdenofidiopathicepilepsyaninequalitydecompositiongeneralizedandsyntheticdifferenceindifferencesstudy AT gengfengchen impactofsocialfactorsandhealthcampaignsontheburdenofidiopathicepilepsyaninequalitydecompositiongeneralizedandsyntheticdifferenceindifferencesstudy AT zemengcao impactofsocialfactorsandhealthcampaignsontheburdenofidiopathicepilepsyaninequalitydecompositiongeneralizedandsyntheticdifferenceindifferencesstudy AT limingshu impactofsocialfactorsandhealthcampaignsontheburdenofidiopathicepilepsyaninequalitydecompositiongeneralizedandsyntheticdifferenceindifferencesstudy |