Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot Study
Introduction: Diabetic foot ulcers (DFUs) represent a severe complication with the potential for lower limb amputations. This is a pilot study investigating the comparative efficacy of platelet-rich plasma (PRP) therapy for chronic DFUs, utilising dressing and perilesional/wound bed injection method...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-02-01
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| Series: | Indian Journal of Physical Medicine & Rehabilitation |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpmr.ijpmr_42_24 |
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| author | Anindya Debnath Jaya Das Badarinath Athani Kurian Zachariah Nidhi Rawat |
| author_facet | Anindya Debnath Jaya Das Badarinath Athani Kurian Zachariah Nidhi Rawat |
| author_sort | Anindya Debnath |
| collection | DOAJ |
| description | Introduction:
Diabetic foot ulcers (DFUs) represent a severe complication with the potential for lower limb amputations. This is a pilot study investigating the comparative efficacy of platelet-rich plasma (PRP) therapy for chronic DFUs, utilising dressing and perilesional/wound bed injection methods.
Methods:
In this prospective comparative interventional study, 15 patients with non-healing chronic DFUs (Wagner Grade 1 or 2) were enrolled in each group. Group 1 received PRP via dressing while Group 2 underwent perilesional and wound bed injections with a 1-week interval between treatments. Evaluation included the Pressure Ulcer Scale for Healing tool, the Lower Extremity Functional Scale and a secondary analysis of the correlation between wound healing and glycaemic control.
Results:
The PRP injection group showed a statistically significant reduction in ulcer size (P < 0.035), exudate (P < 0.026) and tissue type (P < 0.003). Notably, this group exhibited a higher incidence of wound improvement overall. However, no statistically significant correlation emerged between wound healing and glycaemic control.
Conclusion:
The study concludes that PRP injection for chronic DFUs surpasses the effectiveness of PRP dressing alone, proving to be a cost-effective and secure approach. The intervention yielded satisfactory results, expediting the healing process of chronic diabetic ulcers. These findings offer valuable insights for refining treatment approaches for DFUs. |
| format | Article |
| id | doaj-art-500719a49bbb49ba9a1a99de482dff31 |
| institution | Kabale University |
| issn | 0973-2209 2949-8058 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Physical Medicine & Rehabilitation |
| spelling | doaj-art-500719a49bbb49ba9a1a99de482dff312025-08-20T03:40:11ZengWolters Kluwer Medknow PublicationsIndian Journal of Physical Medicine & Rehabilitation0973-22092949-80582025-02-01351142010.4103/ijpmr.ijpmr_42_24Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot StudyAnindya DebnathJaya DasBadarinath AthaniKurian ZachariahNidhi RawatIntroduction: Diabetic foot ulcers (DFUs) represent a severe complication with the potential for lower limb amputations. This is a pilot study investigating the comparative efficacy of platelet-rich plasma (PRP) therapy for chronic DFUs, utilising dressing and perilesional/wound bed injection methods. Methods: In this prospective comparative interventional study, 15 patients with non-healing chronic DFUs (Wagner Grade 1 or 2) were enrolled in each group. Group 1 received PRP via dressing while Group 2 underwent perilesional and wound bed injections with a 1-week interval between treatments. Evaluation included the Pressure Ulcer Scale for Healing tool, the Lower Extremity Functional Scale and a secondary analysis of the correlation between wound healing and glycaemic control. Results: The PRP injection group showed a statistically significant reduction in ulcer size (P < 0.035), exudate (P < 0.026) and tissue type (P < 0.003). Notably, this group exhibited a higher incidence of wound improvement overall. However, no statistically significant correlation emerged between wound healing and glycaemic control. Conclusion: The study concludes that PRP injection for chronic DFUs surpasses the effectiveness of PRP dressing alone, proving to be a cost-effective and secure approach. The intervention yielded satisfactory results, expediting the healing process of chronic diabetic ulcers. These findings offer valuable insights for refining treatment approaches for DFUs.https://journals.lww.com/10.4103/ijpmr.ijpmr_42_24diabetic foot ulcerefficacygrowth factorshealing outcomesplatelet-rich plasmaplatelet-rich plasma injectionulcer healing |
| spellingShingle | Anindya Debnath Jaya Das Badarinath Athani Kurian Zachariah Nidhi Rawat Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot Study Indian Journal of Physical Medicine & Rehabilitation diabetic foot ulcer efficacy growth factors healing outcomes platelet-rich plasma platelet-rich plasma injection ulcer healing |
| title | Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot Study |
| title_full | Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot Study |
| title_fullStr | Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot Study |
| title_full_unstemmed | Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot Study |
| title_short | Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot Study |
| title_sort | comparative prospective study of autologous platelet rich plasma injection versus platelet rich plasma dressing for treating chronic non healing diabetic foot ulcers a pilot study |
| topic | diabetic foot ulcer efficacy growth factors healing outcomes platelet-rich plasma platelet-rich plasma injection ulcer healing |
| url | https://journals.lww.com/10.4103/ijpmr.ijpmr_42_24 |
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