Comparative Prospective Study of Autologous Platelet-rich Plasma Injection versus Platelet-rich Plasma Dressing for Treating Chronic Non-healing Diabetic Foot Ulcers: A Pilot Study
Introduction: Diabetic foot ulcers (DFUs) represent a severe complication with the potential for lower limb amputations. This is a pilot study investigating the comparative efficacy of platelet-rich plasma (PRP) therapy for chronic DFUs, utilising dressing and perilesional/wound bed injection method...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-02-01
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| Series: | Indian Journal of Physical Medicine & Rehabilitation |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpmr.ijpmr_42_24 |
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| Summary: | Introduction:
Diabetic foot ulcers (DFUs) represent a severe complication with the potential for lower limb amputations. This is a pilot study investigating the comparative efficacy of platelet-rich plasma (PRP) therapy for chronic DFUs, utilising dressing and perilesional/wound bed injection methods.
Methods:
In this prospective comparative interventional study, 15 patients with non-healing chronic DFUs (Wagner Grade 1 or 2) were enrolled in each group. Group 1 received PRP via dressing while Group 2 underwent perilesional and wound bed injections with a 1-week interval between treatments. Evaluation included the Pressure Ulcer Scale for Healing tool, the Lower Extremity Functional Scale and a secondary analysis of the correlation between wound healing and glycaemic control.
Results:
The PRP injection group showed a statistically significant reduction in ulcer size (P < 0.035), exudate (P < 0.026) and tissue type (P < 0.003). Notably, this group exhibited a higher incidence of wound improvement overall. However, no statistically significant correlation emerged between wound healing and glycaemic control.
Conclusion:
The study concludes that PRP injection for chronic DFUs surpasses the effectiveness of PRP dressing alone, proving to be a cost-effective and secure approach. The intervention yielded satisfactory results, expediting the healing process of chronic diabetic ulcers. These findings offer valuable insights for refining treatment approaches for DFUs. |
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| ISSN: | 0973-2209 2949-8058 |