Classic paroxysmal nocturnal hemoglobinuria: A puzzling case of hemolytic anemia without cytopenia
Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired complement-mediated hemolytic anemia characterized by continuous destruction of red blood cells leading to dark red or black colored urine. A 42-year-old man has been experiencing recurring jaundice, gastrointestinal discomfort, and h...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Iraqi Journal of Hematology |
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| Online Access: | https://journals.lww.com/10.4103/ijh.ijh_103_24 |
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| author | Majed Abdul Basit Momin Seema Afroze G. Vamshi Krishna Reddy Rahul Dev Singh Rathore |
| author_facet | Majed Abdul Basit Momin Seema Afroze G. Vamshi Krishna Reddy Rahul Dev Singh Rathore |
| author_sort | Majed Abdul Basit Momin |
| collection | DOAJ |
| description | Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired complement-mediated hemolytic anemia characterized by continuous destruction of red blood cells leading to dark red or black colored urine. A 42-year-old man has been experiencing recurring jaundice, gastrointestinal discomfort, and high-colored urine for the past 2 years. His hemogram and antiglobulin tests were normal. The hemolytic anemia workup revealed reticulocytosis, hemoglobinuria, urine hemosiderin, elevated indirect bilirubinemia, and extremely low haptoglobin. A high index of suspicion for PNH prompted the laboratory physician to do flow cytometry, which confirmed the diagnosis of classical PNH. Here, we discuss a case of PNH that remained undiagnosed for years, detailing how we successfully identified a rare and confusing case of hemolytic anemia without cytopenia. |
| format | Article |
| id | doaj-art-4fff8eb33aea47cd9de794744ddd0b7c |
| institution | Kabale University |
| issn | 2072-8069 2543-2702 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Iraqi Journal of Hematology |
| spelling | doaj-art-4fff8eb33aea47cd9de794744ddd0b7c2025-08-20T03:31:34ZengWolters Kluwer Medknow PublicationsIraqi Journal of Hematology2072-80692543-27022025-01-0114112713010.4103/ijh.ijh_103_24Classic paroxysmal nocturnal hemoglobinuria: A puzzling case of hemolytic anemia without cytopeniaMajed Abdul Basit MominSeema AfrozeG. Vamshi Krishna ReddyRahul Dev Singh RathoreParoxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired complement-mediated hemolytic anemia characterized by continuous destruction of red blood cells leading to dark red or black colored urine. A 42-year-old man has been experiencing recurring jaundice, gastrointestinal discomfort, and high-colored urine for the past 2 years. His hemogram and antiglobulin tests were normal. The hemolytic anemia workup revealed reticulocytosis, hemoglobinuria, urine hemosiderin, elevated indirect bilirubinemia, and extremely low haptoglobin. A high index of suspicion for PNH prompted the laboratory physician to do flow cytometry, which confirmed the diagnosis of classical PNH. Here, we discuss a case of PNH that remained undiagnosed for years, detailing how we successfully identified a rare and confusing case of hemolytic anemia without cytopenia.https://journals.lww.com/10.4103/ijh.ijh_103_24flowcytometryintravascular hemolysisparoxysmal nocturnal hemoglobinuria |
| spellingShingle | Majed Abdul Basit Momin Seema Afroze G. Vamshi Krishna Reddy Rahul Dev Singh Rathore Classic paroxysmal nocturnal hemoglobinuria: A puzzling case of hemolytic anemia without cytopenia Iraqi Journal of Hematology flowcytometry intravascular hemolysis paroxysmal nocturnal hemoglobinuria |
| title | Classic paroxysmal nocturnal hemoglobinuria: A puzzling case of hemolytic anemia without cytopenia |
| title_full | Classic paroxysmal nocturnal hemoglobinuria: A puzzling case of hemolytic anemia without cytopenia |
| title_fullStr | Classic paroxysmal nocturnal hemoglobinuria: A puzzling case of hemolytic anemia without cytopenia |
| title_full_unstemmed | Classic paroxysmal nocturnal hemoglobinuria: A puzzling case of hemolytic anemia without cytopenia |
| title_short | Classic paroxysmal nocturnal hemoglobinuria: A puzzling case of hemolytic anemia without cytopenia |
| title_sort | classic paroxysmal nocturnal hemoglobinuria a puzzling case of hemolytic anemia without cytopenia |
| topic | flowcytometry intravascular hemolysis paroxysmal nocturnal hemoglobinuria |
| url | https://journals.lww.com/10.4103/ijh.ijh_103_24 |
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