Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm
Objective: Infrarenal abdominal aortic aneurysm (AAA) and popliteal artery aneurysm (PAA) are localized arterial dilatations with distinct clinical outcomes. This study aimed to comprehensively compare these two types of aneurysms' biomechanical, histological, and immunohistochemical characteri...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | JVS - Vascular Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666350324000907 |
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| author | Marcos Vinícius Melo de Oliveira, MD, PhD Alexandre Malta Brandão, MD, PhD Gina Camillo Rocha Silvestre, BS Alexandre Queiroz Silva, BS Michele Alberto Marques, BS Marcia Martins Reis, PhD Maria de Lourdes Higuchi, MD, PhD Erasmo Simão da Silva, MD, PhD |
| author_facet | Marcos Vinícius Melo de Oliveira, MD, PhD Alexandre Malta Brandão, MD, PhD Gina Camillo Rocha Silvestre, BS Alexandre Queiroz Silva, BS Michele Alberto Marques, BS Marcia Martins Reis, PhD Maria de Lourdes Higuchi, MD, PhD Erasmo Simão da Silva, MD, PhD |
| author_sort | Marcos Vinícius Melo de Oliveira, MD, PhD |
| collection | DOAJ |
| description | Objective: Infrarenal abdominal aortic aneurysm (AAA) and popliteal artery aneurysm (PAA) are localized arterial dilatations with distinct clinical outcomes. This study aimed to comprehensively compare these two types of aneurysms' biomechanical, histological, and immunohistochemical characteristics. Methods: This study included 180 patients with AAA and 18 with PAA. Medical history and imaging data were collected. Biomechanical testing assessed arterial wall mechanical strength and elasticity, and histological and immunohistochemical analyses examined tissue composition and inflammatory markers. Results: PAA wall fragments demonstrate higher failure strain energy (13.36 N/m2 vs 9.95 N/m2; P = .023), a measure of mechanical strength. Regarding immunohistochemical markers, AAA exhibited more B lymphocyte cells in the adventitia (CD20 1475.50 vs 320; P = .003) compared with PAA. Additionally, AAA demonstrated more adipogenic differentiation in the adventitia (PPARgamma 4854.50 vs 778; P = .009), whereas PAA showed more adipogenic differentiation in the intima (KLF5 283.50 vs 77.50; P = .039). Conclusions: PAA wall fragments demonstrate greater mechanical strength compared with AAA wall fragments. In contrast, AAA walls contain a greater number of B lymphocytes within the adventitia compared with PAA walls. Adipogenic differentiation is more pronounced in the adventitia of AAA than in PAA, whereas in PAA, it is more prominent in the intima compared with AAA. Clinical Relevance: The clinical significance of this study lies in its potential to enhance our understanding of the distinct pathophysiological mechanisms underlying abdominal aortic aneurysms, which is often associated with rupture, and popliteal artery aneurysms, which are more prone to thrombosis and distal embolization. By comprehensively comparing the biomechanical, histological, and immunohistochemical aspects of these two aneurysm types, the study aims to illuminate the factors contributing to their differing clinical presentations and outcomes. |
| format | Article |
| id | doaj-art-4ffeb89bb75e4632b75a931539e4d831 |
| institution | Kabale University |
| issn | 2666-3503 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JVS - Vascular Science |
| spelling | doaj-art-4ffeb89bb75e4632b75a931539e4d8312025-01-30T05:15:00ZengElsevierJVS - Vascular Science2666-35032025-01-016100279Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysmMarcos Vinícius Melo de Oliveira, MD, PhD0Alexandre Malta Brandão, MD, PhD1Gina Camillo Rocha Silvestre, BS2Alexandre Queiroz Silva, BS3Michele Alberto Marques, BS4Marcia Martins Reis, PhD5Maria de Lourdes Higuchi, MD, PhD6Erasmo Simão da Silva, MD, PhD7Vascular and Endovascular Division, Department of Surgery, University of São Paulo Medical School, São Paulo, BrazilVascular and Endovascular Division, Department of Surgery, University of São Paulo Medical School, São Paulo, BrazilVascular and Endovascular Division, Department of Surgery, University of São Paulo Medical School, São Paulo, BrazilVascular and Endovascular Division, Department of Surgery, University of São Paulo Medical School, São Paulo, BrazilVascular and Endovascular Division, Department of Surgery, University of São Paulo Medical School, São Paulo, BrazilLaboratory of Cardiac Pathology, Heart Institute, University of São Paulo Medical School, São Paulo, BrazilLaboratory of Cardiac Pathology, Heart Institute, University of São Paulo Medical School, São Paulo, BrazilVascular and Endovascular Division, Department of Surgery, University of São Paulo Medical School, São Paulo, Brazil; Correspondence: Erasmo Simão da Silva, MD, PhD, Vascular Surgeon, Professor, Department of Surgery, LIM02, Anatomia & Cirurgia Vascular, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Avenida Dr. Arnaldo, 455, Sala 1319, Cerqueira Cesar, São Paulo, SP, BrazilObjective: Infrarenal abdominal aortic aneurysm (AAA) and popliteal artery aneurysm (PAA) are localized arterial dilatations with distinct clinical outcomes. This study aimed to comprehensively compare these two types of aneurysms' biomechanical, histological, and immunohistochemical characteristics. Methods: This study included 180 patients with AAA and 18 with PAA. Medical history and imaging data were collected. Biomechanical testing assessed arterial wall mechanical strength and elasticity, and histological and immunohistochemical analyses examined tissue composition and inflammatory markers. Results: PAA wall fragments demonstrate higher failure strain energy (13.36 N/m2 vs 9.95 N/m2; P = .023), a measure of mechanical strength. Regarding immunohistochemical markers, AAA exhibited more B lymphocyte cells in the adventitia (CD20 1475.50 vs 320; P = .003) compared with PAA. Additionally, AAA demonstrated more adipogenic differentiation in the adventitia (PPARgamma 4854.50 vs 778; P = .009), whereas PAA showed more adipogenic differentiation in the intima (KLF5 283.50 vs 77.50; P = .039). Conclusions: PAA wall fragments demonstrate greater mechanical strength compared with AAA wall fragments. In contrast, AAA walls contain a greater number of B lymphocytes within the adventitia compared with PAA walls. Adipogenic differentiation is more pronounced in the adventitia of AAA than in PAA, whereas in PAA, it is more prominent in the intima compared with AAA. Clinical Relevance: The clinical significance of this study lies in its potential to enhance our understanding of the distinct pathophysiological mechanisms underlying abdominal aortic aneurysms, which is often associated with rupture, and popliteal artery aneurysms, which are more prone to thrombosis and distal embolization. By comprehensively comparing the biomechanical, histological, and immunohistochemical aspects of these two aneurysm types, the study aims to illuminate the factors contributing to their differing clinical presentations and outcomes.http://www.sciencedirect.com/science/article/pii/S2666350324000907AortaAbdominalPopliteal arteryAneurysmBiomechanicsImmunohistochemistry |
| spellingShingle | Marcos Vinícius Melo de Oliveira, MD, PhD Alexandre Malta Brandão, MD, PhD Gina Camillo Rocha Silvestre, BS Alexandre Queiroz Silva, BS Michele Alberto Marques, BS Marcia Martins Reis, PhD Maria de Lourdes Higuchi, MD, PhD Erasmo Simão da Silva, MD, PhD Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm JVS - Vascular Science Aorta Abdominal Popliteal artery Aneurysm Biomechanics Immunohistochemistry |
| title | Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm |
| title_full | Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm |
| title_fullStr | Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm |
| title_full_unstemmed | Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm |
| title_short | Comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm |
| title_sort | comparative analysis between abdominal aortic aneurysm and popliteal artery aneurysm |
| topic | Aorta Abdominal Popliteal artery Aneurysm Biomechanics Immunohistochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2666350324000907 |
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