Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative Study
Background: Venous thrombosis is a dreaded complication of long bone fractures. The occurrence of deep vein thrombosis (DVT) may be high in specific cases such as bone tumors with pathological fractures. In this regard, more work is required to establish its correlation. Scanty data are available th...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Journal of Orthopedics, Traumatology and Rehabilitation |
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| Online Access: | https://journals.lww.com/10.4103/jotr.jotr_2_22 |
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| author | Sanjay Kumar Rai Tej Pratap Gupta Bhavya Sirohi Surbhi Rajauria Nitish Khandelwal |
| author_facet | Sanjay Kumar Rai Tej Pratap Gupta Bhavya Sirohi Surbhi Rajauria Nitish Khandelwal |
| author_sort | Sanjay Kumar Rai |
| collection | DOAJ |
| description | Background:
Venous thrombosis is a dreaded complication of long bone fractures. The occurrence of deep vein thrombosis (DVT) may be high in specific cases such as bone tumors with pathological fractures. In this regard, more work is required to establish its correlation. Scanty data are available that shows whether pathological fractures increase the risk of DVT by comparing fracture fixation and replacement surgeries as a treatment. The anticoagulation protocols in published literature might not be suitable for this specific group.
Materials and Methods:
In a retrospective study on patients who underwent surgeries for pathological fracture fixation between September 2010 and October 2020. Their data were collected and analyzed. DVT is diagnosed by clinical sign, D-dimer test, and using color Doppler. The study population (n = 68) was compared and paired with a control group (n = 140) with similar baseline characteristics.
Results:
There were 12 patients (17.64%) in the study group and 8 (5.71%) patients in the control group that developed DVT after performing risk ratio and Student’s t-test and calculating odds ratio (P < 0.031). There was a statistically significant correlation found between the development of DVT with the type of implant used, the presence of neoplastic lesions, and the presence of metastases.
Conclusion:
Patients with a pathological long bone fracture who underwent surgical management are at greater risk for DVT or death due to pulmonary embolism under the current recommended thromboprophylaxis protocol. This risk of developing DVT is increased much fold in the presence of metastasis, chemotherapy, radiotherapy, fracture fixation, and arthroplasty. |
| format | Article |
| id | doaj-art-4ffb2a33fa7d42d8a7396f580406c336 |
| institution | Kabale University |
| issn | 0975-7341 2347-3746 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Orthopedics, Traumatology and Rehabilitation |
| spelling | doaj-art-4ffb2a33fa7d42d8a7396f580406c3362025-02-08T07:31:37ZengWolters Kluwer Medknow PublicationsJournal of Orthopedics, Traumatology and Rehabilitation0975-73412347-37462024-01-0116191410.4103/jotr.jotr_2_22Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative StudySanjay Kumar RaiTej Pratap GuptaBhavya SirohiSurbhi RajauriaNitish KhandelwalBackground: Venous thrombosis is a dreaded complication of long bone fractures. The occurrence of deep vein thrombosis (DVT) may be high in specific cases such as bone tumors with pathological fractures. In this regard, more work is required to establish its correlation. Scanty data are available that shows whether pathological fractures increase the risk of DVT by comparing fracture fixation and replacement surgeries as a treatment. The anticoagulation protocols in published literature might not be suitable for this specific group. Materials and Methods: In a retrospective study on patients who underwent surgeries for pathological fracture fixation between September 2010 and October 2020. Their data were collected and analyzed. DVT is diagnosed by clinical sign, D-dimer test, and using color Doppler. The study population (n = 68) was compared and paired with a control group (n = 140) with similar baseline characteristics. Results: There were 12 patients (17.64%) in the study group and 8 (5.71%) patients in the control group that developed DVT after performing risk ratio and Student’s t-test and calculating odds ratio (P < 0.031). There was a statistically significant correlation found between the development of DVT with the type of implant used, the presence of neoplastic lesions, and the presence of metastases. Conclusion: Patients with a pathological long bone fracture who underwent surgical management are at greater risk for DVT or death due to pulmonary embolism under the current recommended thromboprophylaxis protocol. This risk of developing DVT is increased much fold in the presence of metastasis, chemotherapy, radiotherapy, fracture fixation, and arthroplasty.https://journals.lww.com/10.4103/jotr.jotr_2_22bone tumorbony metastasisdeep vein thrombosisdeep vein thrombosis prophylaxispathologic long bone fracture |
| spellingShingle | Sanjay Kumar Rai Tej Pratap Gupta Bhavya Sirohi Surbhi Rajauria Nitish Khandelwal Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative Study Journal of Orthopedics, Traumatology and Rehabilitation bone tumor bony metastasis deep vein thrombosis deep vein thrombosis prophylaxis pathologic long bone fracture |
| title | Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative Study |
| title_full | Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative Study |
| title_fullStr | Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative Study |
| title_full_unstemmed | Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative Study |
| title_short | Do Pathologic Fractures in Long Bone Following Bony Malignancy Increase the Risk of Venous Thromboembolism? A Comparative Study |
| title_sort | do pathologic fractures in long bone following bony malignancy increase the risk of venous thromboembolism a comparative study |
| topic | bone tumor bony metastasis deep vein thrombosis deep vein thrombosis prophylaxis pathologic long bone fracture |
| url | https://journals.lww.com/10.4103/jotr.jotr_2_22 |
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