Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose
The effects of ultraviolet (254 nm) radiation on a hydrated gelatin-glucose matrix were investigated for the development of a physiologically thermostable substrate for potential use in cell scaffold production. Experiments conducted with a differential scanning calorimeter indicate that ultraviolet...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2014/979636 |
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| _version_ | 1832567095822385152 |
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| author | Evan M. Masutani Christopher K. Kinoshita Travis T. Tanaka Andrew K. D. Ellison Brandon A. Yoza |
| author_facet | Evan M. Masutani Christopher K. Kinoshita Travis T. Tanaka Andrew K. D. Ellison Brandon A. Yoza |
| author_sort | Evan M. Masutani |
| collection | DOAJ |
| description | The effects of ultraviolet (254 nm) radiation on a hydrated gelatin-glucose matrix were investigated for the development of a physiologically thermostable substrate for potential use in cell scaffold production. Experiments conducted with a differential scanning calorimeter indicate that ultraviolet irradiation of gelatin-glucose hydrogels dramatically increases thermal stability such that no melting is observed at temperatures of at least 90°C. The addition of glucose significantly increases the yield of cross-linked product, suggesting that glucose has a role in cross-link formation. Comparisons of lyophilized samples using scanning electron microscopy show that irradiated materials have visibly different densities. |
| format | Article |
| id | doaj-art-4ff9aa52382043999902296967416111 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-4ff9aa523820439999022969674161112025-02-03T01:02:21ZengWileyInternational Journal of Biomaterials1687-87871687-87952014-01-01201410.1155/2014/979636979636Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with GlucoseEvan M. Masutani0Christopher K. Kinoshita1Travis T. Tanaka2Andrew K. D. Ellison3Brandon A. Yoza4Stanford University, Stanford, CA 94305, USAHawaii Natural Energy Institute, University of Hawaii, 1680 East West Road, POST 109, Honolulu, HI 96822, USAHawaii Natural Energy Institute, University of Hawaii, 1680 East West Road, POST 109, Honolulu, HI 96822, USAUniversity of Pennsylvania, Philadelphia, PA 19104, USAHawaii Natural Energy Institute, University of Hawaii, 1680 East West Road, POST 109, Honolulu, HI 96822, USAThe effects of ultraviolet (254 nm) radiation on a hydrated gelatin-glucose matrix were investigated for the development of a physiologically thermostable substrate for potential use in cell scaffold production. Experiments conducted with a differential scanning calorimeter indicate that ultraviolet irradiation of gelatin-glucose hydrogels dramatically increases thermal stability such that no melting is observed at temperatures of at least 90°C. The addition of glucose significantly increases the yield of cross-linked product, suggesting that glucose has a role in cross-link formation. Comparisons of lyophilized samples using scanning electron microscopy show that irradiated materials have visibly different densities.http://dx.doi.org/10.1155/2014/979636 |
| spellingShingle | Evan M. Masutani Christopher K. Kinoshita Travis T. Tanaka Andrew K. D. Ellison Brandon A. Yoza Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose International Journal of Biomaterials |
| title | Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose |
| title_full | Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose |
| title_fullStr | Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose |
| title_full_unstemmed | Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose |
| title_short | Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose |
| title_sort | increasing thermal stability of gelatin by uv induced cross linking with glucose |
| url | http://dx.doi.org/10.1155/2014/979636 |
| work_keys_str_mv | AT evanmmasutani increasingthermalstabilityofgelatinbyuvinducedcrosslinkingwithglucose AT christopherkkinoshita increasingthermalstabilityofgelatinbyuvinducedcrosslinkingwithglucose AT travisttanaka increasingthermalstabilityofgelatinbyuvinducedcrosslinkingwithglucose AT andrewkdellison increasingthermalstabilityofgelatinbyuvinducedcrosslinkingwithglucose AT brandonayoza increasingthermalstabilityofgelatinbyuvinducedcrosslinkingwithglucose |