Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial
Abstract Head and neck radiotherapy quantitatively and qualitatively compromises salivary flow, and salivary substitutes have the potential to alleviate the symptoms. This study aims to assess the effectiveness of two salivary substitutes in relieving symptoms of radiotherapy-induced xerostomia thro...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pesquisa Odontológica
2025-06-01
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| Series: | Brazilian Oral Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242025000101554&lng=en&tlng=en |
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| _version_ | 1849744858332266496 |
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| author | Isabella Silveira SAVO Samanta Vicente de OLIVEIRA Gabriela Banacu de MELO Celso LEMOS Camila de Barros GALLO |
| author_facet | Isabella Silveira SAVO Samanta Vicente de OLIVEIRA Gabriela Banacu de MELO Celso LEMOS Camila de Barros GALLO |
| author_sort | Isabella Silveira SAVO |
| collection | DOAJ |
| description | Abstract Head and neck radiotherapy quantitatively and qualitatively compromises salivary flow, and salivary substitutes have the potential to alleviate the symptoms. This study aims to assess the effectiveness of two salivary substitutes in relieving symptoms of radiotherapy-induced xerostomia through a double-blind randomized controlled trial. Twenty-four patients were selected from a dental oncology clinic and randomly assigned to the over-the-counter or compounded mouthwash group. Each patient was instructed to rinse their oral cavity with the assigned solution three times a day for 30 days. Both participants and researchers were blinded to the product used during the trial. The impact of xerostomia was assessed using a numerical rating scale and validated questionnaires on oral health-related quality of life and xerostomia, administered before and after the intervention and subsequently compared. Both groups exhibited a statistically significant reduction in xerostomia symptoms. The studied salivary substitutes produced transient beneficial effects on complaints of radiotherapy-induced xerostomia. |
| format | Article |
| id | doaj-art-4ff81cd2ffde46dd8d0a0598e75c685c |
| institution | DOAJ |
| issn | 1807-3107 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj-art-4ff81cd2ffde46dd8d0a0598e75c685c2025-08-20T03:07:35ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1807-31072025-06-013910.1590/1807-3107bor-2025.vol39.057Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trialIsabella Silveira SAVOhttps://orcid.org/0000-0002-6645-1133Samanta Vicente de OLIVEIRAhttps://orcid.org/0000-0002-9653-3893Gabriela Banacu de MELOhttps://orcid.org/0000-0001-5136-9383Celso LEMOShttps://orcid.org/0000-0002-3372-6719Camila de Barros GALLOhttps://orcid.org/0000-0002-8141-6029Abstract Head and neck radiotherapy quantitatively and qualitatively compromises salivary flow, and salivary substitutes have the potential to alleviate the symptoms. This study aims to assess the effectiveness of two salivary substitutes in relieving symptoms of radiotherapy-induced xerostomia through a double-blind randomized controlled trial. Twenty-four patients were selected from a dental oncology clinic and randomly assigned to the over-the-counter or compounded mouthwash group. Each patient was instructed to rinse their oral cavity with the assigned solution three times a day for 30 days. Both participants and researchers were blinded to the product used during the trial. The impact of xerostomia was assessed using a numerical rating scale and validated questionnaires on oral health-related quality of life and xerostomia, administered before and after the intervention and subsequently compared. Both groups exhibited a statistically significant reduction in xerostomia symptoms. The studied salivary substitutes produced transient beneficial effects on complaints of radiotherapy-induced xerostomia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242025000101554&lng=en&tlng=enXerostomiaRadiotherapySaliva, ArtificialMouthwashesQuality of Life |
| spellingShingle | Isabella Silveira SAVO Samanta Vicente de OLIVEIRA Gabriela Banacu de MELO Celso LEMOS Camila de Barros GALLO Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial Brazilian Oral Research Xerostomia Radiotherapy Saliva, Artificial Mouthwashes Quality of Life |
| title | Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial |
| title_full | Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial |
| title_fullStr | Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial |
| title_full_unstemmed | Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial |
| title_short | Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial |
| title_sort | over the counter and compounded mouthwashes for radiotherapy induced xerostomia a randomized controlled trial |
| topic | Xerostomia Radiotherapy Saliva, Artificial Mouthwashes Quality of Life |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242025000101554&lng=en&tlng=en |
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