Machine learning based intratumor heterogeneity related signature for prognosis and drug sensitivity in breast cancer

Abstract Intratumor heterogeneity (ITH) is involved in tumor evolution and drug resistance. Drug sensitivity shows discrepancy in different breast cancer (BRCA) patients due to ITH. The genes mediating ITH in BRCA and their role in predicting prognosis and drug sensitivity is not yet elucidated. An...

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Bibliographic Details
Main Authors: Hongcai Chen, Minna Chen, Cui Yang, Tingting Tang, Wende Wang, Wenwu Xue
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-92695-1
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