The Role of MicroRNAs in Regulatory T Cells
MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis....
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/3232061 |
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| _version_ | 1832561143279779840 |
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| author | Chao Liu Nannan Li Guijian Liu |
| author_facet | Chao Liu Nannan Li Guijian Liu |
| author_sort | Chao Liu |
| collection | DOAJ |
| description | MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. Here, we review the recent progress in understanding the roles of microRNAs in Treg and their dysregulation in immune-related diseases. This ongoing research continues to expand the understanding of Treg regulation and the mechanisms of immune disorders. |
| format | Article |
| id | doaj-art-4ff6d6a7d65e4591b80bc37ef4f0a307 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-4ff6d6a7d65e4591b80bc37ef4f0a3072025-02-03T01:25:49ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/32320613232061The Role of MicroRNAs in Regulatory T CellsChao Liu0Nannan Li1Guijian Liu2Clinical Laboratory, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, ChinaFeiyan Biotechnology Company Limited, Beijing, ChinaClinical Laboratory, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, ChinaMicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. Here, we review the recent progress in understanding the roles of microRNAs in Treg and their dysregulation in immune-related diseases. This ongoing research continues to expand the understanding of Treg regulation and the mechanisms of immune disorders.http://dx.doi.org/10.1155/2020/3232061 |
| spellingShingle | Chao Liu Nannan Li Guijian Liu The Role of MicroRNAs in Regulatory T Cells Journal of Immunology Research |
| title | The Role of MicroRNAs in Regulatory T Cells |
| title_full | The Role of MicroRNAs in Regulatory T Cells |
| title_fullStr | The Role of MicroRNAs in Regulatory T Cells |
| title_full_unstemmed | The Role of MicroRNAs in Regulatory T Cells |
| title_short | The Role of MicroRNAs in Regulatory T Cells |
| title_sort | role of micrornas in regulatory t cells |
| url | http://dx.doi.org/10.1155/2020/3232061 |
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