Breaking Immunological Tolerance through OX40 (CD134)
Immunological tolerance represents a mechanism by which cells of the host remain protected from the immune system. Breaking of immunological tolerance can result in a variety of autoimmune diseases such as rheumatoid arthritis, diabetes, and multiple sclerosis. The reasons for tolerance breaking dow...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.341 |
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| _version_ | 1850224382015700992 |
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| author | Pratima Bansal-Pakala Michael Croft |
| author_facet | Pratima Bansal-Pakala Michael Croft |
| author_sort | Pratima Bansal-Pakala |
| collection | DOAJ |
| description | Immunological tolerance represents a mechanism by which cells of the host remain protected from the immune system. Breaking of immunological tolerance can result in a variety of autoimmune diseases such as rheumatoid arthritis, diabetes, and multiple sclerosis. The reasons for tolerance breaking down and autoimmune processes arising are largely unknown but of obvious interest for therapeutic intervention of these diseases. Although reversal of the tolerant state is generally unwanted, there are instances where this may be of benefit to the host. In particular, one way a cancerous cell escapes being targeted by the immune system is through tolerance mechanisms that in effect turn off the reactivity of T lymphocytes that can respond to tumor-associated peptides. Thus tolerance represents a major obstacle in developing effective immunotherapy against tumors. The molecules that are involved in regulating immunological tolerance are then of interest as they may be great targets for positively or negatively manipulating the tolerance process. |
| format | Article |
| id | doaj-art-4ff405b4698e44aa83ea346f1c89b247 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4ff405b4698e44aa83ea346f1c89b2472025-08-20T02:05:38ZengWileyThe Scientific World Journal1537-744X2001-01-01163363510.1100/tsw.2001.341Breaking Immunological Tolerance through OX40 (CD134)Pratima Bansal-Pakala0Michael Croft1Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, Ca, USADivision of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, Ca, USAImmunological tolerance represents a mechanism by which cells of the host remain protected from the immune system. Breaking of immunological tolerance can result in a variety of autoimmune diseases such as rheumatoid arthritis, diabetes, and multiple sclerosis. The reasons for tolerance breaking down and autoimmune processes arising are largely unknown but of obvious interest for therapeutic intervention of these diseases. Although reversal of the tolerant state is generally unwanted, there are instances where this may be of benefit to the host. In particular, one way a cancerous cell escapes being targeted by the immune system is through tolerance mechanisms that in effect turn off the reactivity of T lymphocytes that can respond to tumor-associated peptides. Thus tolerance represents a major obstacle in developing effective immunotherapy against tumors. The molecules that are involved in regulating immunological tolerance are then of interest as they may be great targets for positively or negatively manipulating the tolerance process.http://dx.doi.org/10.1100/tsw.2001.341 |
| spellingShingle | Pratima Bansal-Pakala Michael Croft Breaking Immunological Tolerance through OX40 (CD134) The Scientific World Journal |
| title | Breaking Immunological Tolerance through OX40 (CD134) |
| title_full | Breaking Immunological Tolerance through OX40 (CD134) |
| title_fullStr | Breaking Immunological Tolerance through OX40 (CD134) |
| title_full_unstemmed | Breaking Immunological Tolerance through OX40 (CD134) |
| title_short | Breaking Immunological Tolerance through OX40 (CD134) |
| title_sort | breaking immunological tolerance through ox40 cd134 |
| url | http://dx.doi.org/10.1100/tsw.2001.341 |
| work_keys_str_mv | AT pratimabansalpakala breakingimmunologicaltolerancethroughox40cd134 AT michaelcroft breakingimmunologicaltolerancethroughox40cd134 |