Days alive and out of hospital in patients with wild type transthyretin amyloidosis: cohort study
Abstract While overall survival has been extensively studied in amyloidosis, less attention has been given to patient-centered measures that integrate morbidity and mortality. Days Alive and Out of Hospital (DAOH) is an emerging metric that captures both aspects and has potential utility in the eval...
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-14526-7 |
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| author | Mariana Vaena María Adela Aguirre Teo Epstein Agustín Schalum Facundo Ezequiel Hilbert María Lourdes Posadas-Martínez Marcelina Carretero |
| author_facet | Mariana Vaena María Adela Aguirre Teo Epstein Agustín Schalum Facundo Ezequiel Hilbert María Lourdes Posadas-Martínez Marcelina Carretero |
| author_sort | Mariana Vaena |
| collection | DOAJ |
| description | Abstract While overall survival has been extensively studied in amyloidosis, less attention has been given to patient-centered measures that integrate morbidity and mortality. Days Alive and Out of Hospital (DAOH) is an emerging metric that captures both aspects and has potential utility in the evaluation of disease impact.To describe DAOH in patients with wild-type transthyretin amyloidosis (ATTRwt) and explore factors associated with DAOH.Retrospective cohort study used the Institutional Registry of Amyloidosis database of the Hospital Italiano de Buenos Aires (2015–2023). All patients with ATTRwt amyloidosis enrolled in the registry and affiliated with the health maintenance organization of the hospital were included. DAOH were estimated at 1, 3 and 5 years. Associations between DAOH and risk factors were evaluated.61 cases were included. The median age was 83 years, and 89% were male. Median (IQR) DAOH were 365 (353–365), 998 (553–1094) and 1314 (740–1769) days for 1, 3, and 5 years, respectively. Atrial fibrillation was associated with lower DAOH.DAOH is a simple, reproducible metric. Our findings highlight the importance of considering morbidity, not just mortality, in patients with ATTRwt amyloidosis. |
| format | Article |
| id | doaj-art-4ff21b9893df41e29eb6ee79a641b130 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-4ff21b9893df41e29eb6ee79a641b1302025-08-24T11:26:00ZengNature PortfolioScientific Reports2045-23222025-08-011511710.1038/s41598-025-14526-7Days alive and out of hospital in patients with wild type transthyretin amyloidosis: cohort studyMariana Vaena0María Adela Aguirre1Teo Epstein2Agustín Schalum3Facundo Ezequiel Hilbert4María Lourdes Posadas-Martínez5Marcelina Carretero6Internal Department Medicine, Hospital Italiano de Buenos AiresInternal Department Medicine, Hospital Italiano de Buenos AiresInternal Department Medicine, Hospital Italiano de Buenos AiresUniversity Hospital ItalianoUniversity Hospital ItalianoInstitute of Translational Medicine and Biomedical Engineering, CONICETInternal Medicine Research Unit, Internal Department Medicine, Hospital Italiano de Buenos AiresAbstract While overall survival has been extensively studied in amyloidosis, less attention has been given to patient-centered measures that integrate morbidity and mortality. Days Alive and Out of Hospital (DAOH) is an emerging metric that captures both aspects and has potential utility in the evaluation of disease impact.To describe DAOH in patients with wild-type transthyretin amyloidosis (ATTRwt) and explore factors associated with DAOH.Retrospective cohort study used the Institutional Registry of Amyloidosis database of the Hospital Italiano de Buenos Aires (2015–2023). All patients with ATTRwt amyloidosis enrolled in the registry and affiliated with the health maintenance organization of the hospital were included. DAOH were estimated at 1, 3 and 5 years. Associations between DAOH and risk factors were evaluated.61 cases were included. The median age was 83 years, and 89% were male. Median (IQR) DAOH were 365 (353–365), 998 (553–1094) and 1314 (740–1769) days for 1, 3, and 5 years, respectively. Atrial fibrillation was associated with lower DAOH.DAOH is a simple, reproducible metric. Our findings highlight the importance of considering morbidity, not just mortality, in patients with ATTRwt amyloidosis.https://doi.org/10.1038/s41598-025-14526-7Transthyretin proteinMortalityMorbidityPatient outcome assessmentValue-Based health care |
| spellingShingle | Mariana Vaena María Adela Aguirre Teo Epstein Agustín Schalum Facundo Ezequiel Hilbert María Lourdes Posadas-Martínez Marcelina Carretero Days alive and out of hospital in patients with wild type transthyretin amyloidosis: cohort study Scientific Reports Transthyretin protein Mortality Morbidity Patient outcome assessment Value-Based health care |
| title | Days alive and out of hospital in patients with wild type transthyretin amyloidosis: cohort study |
| title_full | Days alive and out of hospital in patients with wild type transthyretin amyloidosis: cohort study |
| title_fullStr | Days alive and out of hospital in patients with wild type transthyretin amyloidosis: cohort study |
| title_full_unstemmed | Days alive and out of hospital in patients with wild type transthyretin amyloidosis: cohort study |
| title_short | Days alive and out of hospital in patients with wild type transthyretin amyloidosis: cohort study |
| title_sort | days alive and out of hospital in patients with wild type transthyretin amyloidosis cohort study |
| topic | Transthyretin protein Mortality Morbidity Patient outcome assessment Value-Based health care |
| url | https://doi.org/10.1038/s41598-025-14526-7 |
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