The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis
Background. The Warthin-like variant of papillary thyroid (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumors of the salivary glands. Due to its rarity, the clinicopathologic and molecular features of WLPTC remain unclear. Methods. Of the 2,139 patients who under...
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2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/456027 |
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| author | Min-kyung Yeo Ja Seong Bae Sohee Lee Min-Hee Kim Dong-Jun Lim Youn Soo Lee Chan Kwon Jung |
| author_facet | Min-kyung Yeo Ja Seong Bae Sohee Lee Min-Hee Kim Dong-Jun Lim Youn Soo Lee Chan Kwon Jung |
| author_sort | Min-kyung Yeo |
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| description | Background. The Warthin-like variant of papillary thyroid (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumors of the salivary glands. Due to its rarity, the clinicopathologic and molecular features of WLPTC remain unclear. Methods. Of the 2,139 patients who underwent surgical treatment for PTC from 2012 to 2013, 40 patients with WLPTC were identified and compared to 200 consecutive patients with classic PTC. BRAF mutation was tested with pyrosequencing. Results. There were no significant differences in age, predilection for women, multifocality, extrathyroidal extension, or lymph node metastasis between WLPTC and classic PTC. However, WLPTCs were more commonly associated with Hashimoto’s thyroiditis than classic PTCs (93% versus 36%, resp., P < 0.001) and showed significantly lower rate of BRAF mutation when compared to classic PTCs (65% versus 84%, resp., P = 0.007). In classic PTC, the frequency of BRAF mutations was negatively correlated with coexisting Hashimoto’s thyroiditis. When we compared WLPTC and classic PTC in the patients with coexisting Hashimoto’s thyroiditis, there were no significant differences in clinicopathologic characteristics or the BRAF mutational rate between the two groups. Conclusions. Patients with WLPTC have similar demographic, clinical, pathologic, and molecular characteristics to those with classic PTC coexisting with Hashimoto’s thyroiditis. |
| format | Article |
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| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-4fed73cc494e45c9a6baaf748ef51fd62025-02-03T07:26:19ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/456027456027The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s ThyroiditisMin-kyung Yeo0Ja Seong Bae1Sohee Lee2Min-Hee Kim3Dong-Jun Lim4Youn Soo Lee5Chan Kwon Jung6Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaDepartment of Surgery, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaDepartment of Surgery, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaDepartment of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of KoreaBackground. The Warthin-like variant of papillary thyroid (WLPTC) is a rare subtype of papillary thyroid carcinoma (PTC) resembling Warthin tumors of the salivary glands. Due to its rarity, the clinicopathologic and molecular features of WLPTC remain unclear. Methods. Of the 2,139 patients who underwent surgical treatment for PTC from 2012 to 2013, 40 patients with WLPTC were identified and compared to 200 consecutive patients with classic PTC. BRAF mutation was tested with pyrosequencing. Results. There were no significant differences in age, predilection for women, multifocality, extrathyroidal extension, or lymph node metastasis between WLPTC and classic PTC. However, WLPTCs were more commonly associated with Hashimoto’s thyroiditis than classic PTCs (93% versus 36%, resp., P < 0.001) and showed significantly lower rate of BRAF mutation when compared to classic PTCs (65% versus 84%, resp., P = 0.007). In classic PTC, the frequency of BRAF mutations was negatively correlated with coexisting Hashimoto’s thyroiditis. When we compared WLPTC and classic PTC in the patients with coexisting Hashimoto’s thyroiditis, there were no significant differences in clinicopathologic characteristics or the BRAF mutational rate between the two groups. Conclusions. Patients with WLPTC have similar demographic, clinical, pathologic, and molecular characteristics to those with classic PTC coexisting with Hashimoto’s thyroiditis.http://dx.doi.org/10.1155/2015/456027 |
| spellingShingle | Min-kyung Yeo Ja Seong Bae Sohee Lee Min-Hee Kim Dong-Jun Lim Youn Soo Lee Chan Kwon Jung The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis International Journal of Endocrinology |
| title | The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis |
| title_full | The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis |
| title_fullStr | The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis |
| title_full_unstemmed | The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis |
| title_short | The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis |
| title_sort | warthin like variant of papillary thyroid carcinoma a comparison with classic type in the patients with coexisting hashimoto s thyroiditis |
| url | http://dx.doi.org/10.1155/2015/456027 |
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