Reticulophagy and Ribophagy: Regulated Degradation of Protein Production Factories
During autophagy, cytosol, protein aggregates, and organelles are sequestered into double-membrane vesicles called autophagosomes and delivered to the lysosome/vacuole for breakdown and recycling of their basic components. In all eukaryotes this pathway is important for adaptation to stress conditio...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/182834 |
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| _version_ | 1850224496808558592 |
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| author | Eduardo Cebollero Fulvio Reggiori Claudine Kraft |
| author_facet | Eduardo Cebollero Fulvio Reggiori Claudine Kraft |
| author_sort | Eduardo Cebollero |
| collection | DOAJ |
| description | During autophagy, cytosol, protein aggregates, and organelles are sequestered into double-membrane vesicles called autophagosomes and delivered to the lysosome/vacuole for breakdown and recycling of their basic components. In all eukaryotes this pathway is important for adaptation to stress conditions such as nutrient deprivation, as well as to regulate intracellular homeostasis by adjusting organelle number and clearing damaged structures. For a long time, starvation-induced autophagy has been viewed as a nonselective transport pathway; however, recent studies have revealed that autophagy is able to selectively engulf specific structures, ranging from proteins to entire organelles. In this paper, we discuss recent findings on the mechanisms and physiological implications of two selective types of autophagy: ribophagy, the specific degradation of ribosomes, and reticulophagy, the selective elimination of portions of the ER. |
| format | Article |
| id | doaj-art-4fed165a13fb4defa41f272b764ab221 |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-4fed165a13fb4defa41f272b764ab2212025-08-20T02:05:36ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/182834182834Reticulophagy and Ribophagy: Regulated Degradation of Protein Production FactoriesEduardo Cebollero0Fulvio Reggiori1Claudine Kraft2Department of Cell Biology and Institute of Biomembranes, University Medical Centre Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Cell Biology and Institute of Biomembranes, University Medical Centre Utrecht, 3584 CX Utrecht, The NetherlandsMax F. Perutz Laboratories, University of Vienna, 1030 Vienna, AustriaDuring autophagy, cytosol, protein aggregates, and organelles are sequestered into double-membrane vesicles called autophagosomes and delivered to the lysosome/vacuole for breakdown and recycling of their basic components. In all eukaryotes this pathway is important for adaptation to stress conditions such as nutrient deprivation, as well as to regulate intracellular homeostasis by adjusting organelle number and clearing damaged structures. For a long time, starvation-induced autophagy has been viewed as a nonselective transport pathway; however, recent studies have revealed that autophagy is able to selectively engulf specific structures, ranging from proteins to entire organelles. In this paper, we discuss recent findings on the mechanisms and physiological implications of two selective types of autophagy: ribophagy, the specific degradation of ribosomes, and reticulophagy, the selective elimination of portions of the ER.http://dx.doi.org/10.1155/2012/182834 |
| spellingShingle | Eduardo Cebollero Fulvio Reggiori Claudine Kraft Reticulophagy and Ribophagy: Regulated Degradation of Protein Production Factories International Journal of Cell Biology |
| title | Reticulophagy and Ribophagy: Regulated Degradation of Protein Production Factories |
| title_full | Reticulophagy and Ribophagy: Regulated Degradation of Protein Production Factories |
| title_fullStr | Reticulophagy and Ribophagy: Regulated Degradation of Protein Production Factories |
| title_full_unstemmed | Reticulophagy and Ribophagy: Regulated Degradation of Protein Production Factories |
| title_short | Reticulophagy and Ribophagy: Regulated Degradation of Protein Production Factories |
| title_sort | reticulophagy and ribophagy regulated degradation of protein production factories |
| url | http://dx.doi.org/10.1155/2012/182834 |
| work_keys_str_mv | AT eduardocebollero reticulophagyandribophagyregulateddegradationofproteinproductionfactories AT fulvioreggiori reticulophagyandribophagyregulateddegradationofproteinproductionfactories AT claudinekraft reticulophagyandribophagyregulateddegradationofproteinproductionfactories |