PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity
The examination of PANoptosis in colorectal cancer is particularly important, as many tumor cells can evade apoptotic cell death while continuing to proliferate through inflammatory mediators and creating an immunosuppressive environment. The PANoptosome functions as a regulatory complex that unites...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/10/730 |
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| author | Györgyi Műzes Ferenc Sipos |
| author_facet | Györgyi Műzes Ferenc Sipos |
| author_sort | Györgyi Műzes |
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| description | The examination of PANoptosis in colorectal cancer is particularly important, as many tumor cells can evade apoptotic cell death while continuing to proliferate through inflammatory mediators and creating an immunosuppressive environment. The PANoptosome functions as a regulatory complex that unites proteins governing pyroptotic, apoptotic, and necroptotic pathways, rather than allowing distinct death pathways to compete. The expression and functional status of key molecules within the PANoptosome, such as ZBP1, RIPK1, RIPK3, CASP8, and ASC, may influence tumor viability and immune detection. The tumorigenic impact of PANoptosis is complex and predominantly manifests through chronic inflammation, immune response modulation, and changes in the tumor microenvironment. PANoptosis also aids in the defense against colon cancer by directly eradicating tumor cells and modifying the cellular environment. The expression profile of PANoptosis components may possess prognostic and predictive significance. The therapeutic ramifications of PANoptosis in colorectal cancer are now being investigated through many avenues. It provides an opportunity to develop targeted therapeutic techniques. In contrast, it may also be pertinent in conjunction with immunotherapy, as PANoptosis signifies an immunogenic type of cell death and may consequently enhance the anti-tumor immune response. A thorough comprehension of how these parameters influence PANoptosis is crucial for practical implementation. |
| format | Article |
| id | doaj-art-4fe50daecd5c4f2a8739d18b665bea5b |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj-art-4fe50daecd5c4f2a8739d18b665bea5b2025-08-20T03:47:53ZengMDPI AGCells2073-44092025-05-01141073010.3390/cells14100730PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic OpportunityGyörgyi Műzes0Ferenc Sipos1Immunology Division, Department of Internal Medicine and Hematology, Semmelweis University, 1088 Budapest, HungaryImmunology Division, Department of Internal Medicine and Hematology, Semmelweis University, 1088 Budapest, HungaryThe examination of PANoptosis in colorectal cancer is particularly important, as many tumor cells can evade apoptotic cell death while continuing to proliferate through inflammatory mediators and creating an immunosuppressive environment. The PANoptosome functions as a regulatory complex that unites proteins governing pyroptotic, apoptotic, and necroptotic pathways, rather than allowing distinct death pathways to compete. The expression and functional status of key molecules within the PANoptosome, such as ZBP1, RIPK1, RIPK3, CASP8, and ASC, may influence tumor viability and immune detection. The tumorigenic impact of PANoptosis is complex and predominantly manifests through chronic inflammation, immune response modulation, and changes in the tumor microenvironment. PANoptosis also aids in the defense against colon cancer by directly eradicating tumor cells and modifying the cellular environment. The expression profile of PANoptosis components may possess prognostic and predictive significance. The therapeutic ramifications of PANoptosis in colorectal cancer are now being investigated through many avenues. It provides an opportunity to develop targeted therapeutic techniques. In contrast, it may also be pertinent in conjunction with immunotherapy, as PANoptosis signifies an immunogenic type of cell death and may consequently enhance the anti-tumor immune response. A thorough comprehension of how these parameters influence PANoptosis is crucial for practical implementation.https://www.mdpi.com/2073-4409/14/10/730PANoptosiscolorectal cancerPANoptosomeapoptosispyroptosisnecroptosis |
| spellingShingle | Györgyi Műzes Ferenc Sipos PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity Cells PANoptosis colorectal cancer PANoptosome apoptosis pyroptosis necroptosis |
| title | PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity |
| title_full | PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity |
| title_fullStr | PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity |
| title_full_unstemmed | PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity |
| title_short | PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity |
| title_sort | panoptosis as a two edged sword in colorectal cancer a pathogenic mechanism and therapeutic opportunity |
| topic | PANoptosis colorectal cancer PANoptosome apoptosis pyroptosis necroptosis |
| url | https://www.mdpi.com/2073-4409/14/10/730 |
| work_keys_str_mv | AT gyorgyimuzes panoptosisasatwoedgedswordincolorectalcancerapathogenicmechanismandtherapeuticopportunity AT ferencsipos panoptosisasatwoedgedswordincolorectalcancerapathogenicmechanismandtherapeuticopportunity |