Preventative Cancer Vaccine-Elicited Human Anti-MUC1 Antibodies Have Multiple Effector Functions

Preventative Cancer Vaccine-Elicited Human Anti-MUC1 Antibodies Have Multiple Effector Functions

Background/Objectives: Mucin-1 (MUC1) is a transmembrane glycoprotein that is overexpressed and hypoglycosylated in premalignant and malignant epithelial cells compared to normal cells, creating a target antigen for humoral and cellular immunity. Healthy individuals with a history of advanced coloni...

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Bibliographic Details
Main Authors: Michelle L. McKeague, Jason Lohmueller, Matthew T. Dracz, Najla Saadallah, Eric D. Ricci, Donella M. Beckwith, Ramya Ayyalasomayajula, Maré Cudic, Olivera J. Finn
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Antibodies
Subjects:
mucin-1
phagocytosis
trogocytosis
NK cell
monocyte
neutrophil
Online Access:https://www.mdpi.com/2073-4468/13/4/85
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