The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake
Low doses of radiation affect the response of cells to higher doses; this phenomenon is called radio-adaptive response, which leads to increased resistance to subsequent higher doses. We have investigated the adaptive response using 0.37 MBq priming dose of I-131 followed by 296–444 MBq challenging...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2018-10-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_83_17 |
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| author | Zahra Fazeli Ali Monfared Seyed Zakavi Mehrangiz Amiri Ebrahim Zabihi Sajad Borzoueisileh Amir Gholami Kourosh Gorji |
| author_facet | Zahra Fazeli Ali Monfared Seyed Zakavi Mehrangiz Amiri Ebrahim Zabihi Sajad Borzoueisileh Amir Gholami Kourosh Gorji |
| author_sort | Zahra Fazeli |
| collection | DOAJ |
| description | Low doses of radiation affect the response of cells to higher doses; this phenomenon is called radio-adaptive response, which leads to increased resistance to subsequent higher doses. We have investigated the adaptive response using 0.37 MBq priming dose of I-131 followed by 296–444 MBq challenging dose in peripheral human lymphocyte cells. The study was performed on 42 patients with Graves' disease and 29 healthy adult persons as a control group. The patients were divided into two groups. In the first group, patients were referred for radioactive iodine therapy with a specific dose, and iodine was given to them on the day of referral. In the second group, patients were referred for radioactive iodine uptake and radioactive iodine therapy, and iodine uptake was initially performed, then 24 h later, iodine therapy was done. In both groups, 1 month after treatment, blood samples were taken to cytokinesis-block micronucleus (MN) assay. The number of MN in binuclear lymphocyte cells was counted as an end point test. The mean frequency of MN in first, second, and control groups was 75.86 ± 12.68, 71.45 ± 12.56, and 20.06 ± 7.30, respectively. Our results showed that the frequency of total chromosome aberration in both radiation groups was higher than controls. However, in the first group was higher than another group, but their difference was not statistically significant. According to the results, we cannot approve the hypothesis that 0.37 MBq I-131 administration before iodine therapy could induce a radio-adaptive response in lymphocytes of Graves' patients. |
| format | Article |
| id | doaj-art-4fe061a958874e8bbcbff4a9c10c7cb7 |
| institution | DOAJ |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
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| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-4fe061a958874e8bbcbff4a9c10c7cb72025-08-20T02:54:43ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122018-10-01170427027410.4103/wjnm.WJNM_83_17The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptakeZahra Fazeli0Ali Monfared1Seyed Zakavi2Mehrangiz Amiri3Ebrahim Zabihi4Sajad Borzoueisileh5Amir Gholami6Kourosh Gorji7Student Research Committee, Babol University of Medical Sciences, BabolCancer Research Center, Babol University of Medical Sciences, BabolDepartment of Nuclear Medicine, Mashhad University of Medical Sciences, MashhadNuclear Medicine Department, Babol University of Medical Sciences, BabolCellular and Molecular Research Center, Babol University of Medical Sciences, BabolCellular and Molecular Research Center, Babol University of Medical Sciences, BabolNuclear Medicine Department, Babol University of Medical Sciences, BabolDepartment of Medical Physics Radiobiology and Radiation Protection, Babol University of Medical Sciences, BabolLow doses of radiation affect the response of cells to higher doses; this phenomenon is called radio-adaptive response, which leads to increased resistance to subsequent higher doses. We have investigated the adaptive response using 0.37 MBq priming dose of I-131 followed by 296–444 MBq challenging dose in peripheral human lymphocyte cells. The study was performed on 42 patients with Graves' disease and 29 healthy adult persons as a control group. The patients were divided into two groups. In the first group, patients were referred for radioactive iodine therapy with a specific dose, and iodine was given to them on the day of referral. In the second group, patients were referred for radioactive iodine uptake and radioactive iodine therapy, and iodine uptake was initially performed, then 24 h later, iodine therapy was done. In both groups, 1 month after treatment, blood samples were taken to cytokinesis-block micronucleus (MN) assay. The number of MN in binuclear lymphocyte cells was counted as an end point test. The mean frequency of MN in first, second, and control groups was 75.86 ± 12.68, 71.45 ± 12.56, and 20.06 ± 7.30, respectively. Our results showed that the frequency of total chromosome aberration in both radiation groups was higher than controls. However, in the first group was higher than another group, but their difference was not statistically significant. According to the results, we cannot approve the hypothesis that 0.37 MBq I-131 administration before iodine therapy could induce a radio-adaptive response in lymphocytes of Graves' patients.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_83_17radioactive iodine therapyradioactive iodine uptakeradio-adaptive response |
| spellingShingle | Zahra Fazeli Ali Monfared Seyed Zakavi Mehrangiz Amiri Ebrahim Zabihi Sajad Borzoueisileh Amir Gholami Kourosh Gorji The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake World Journal of Nuclear Medicine radioactive iodine therapy radioactive iodine uptake radio-adaptive response |
| title | The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake |
| title_full | The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake |
| title_fullStr | The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake |
| title_full_unstemmed | The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake |
| title_short | The assessment of radio-adaptive response in graves' hyperthyroidism patients following radioactive iodine uptake |
| title_sort | assessment of radio adaptive response in graves hyperthyroidism patients following radioactive iodine uptake |
| topic | radioactive iodine therapy radioactive iodine uptake radio-adaptive response |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_83_17 |
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