Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Abstract Background Neurodegenerative diseases (NDs), including Alzheimer‘s disease, Parkinson‘s disease, and Huntington‘s disease, are complex and challenging due to their intricate pathophysiology and limited treatment options. Methods This review systematically sourced articles related to neurode...

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Main Authors: Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Animal Models and Experimental Medicine
Subjects:
neurodegeneration
neurodegenerative diseases
neuroprotection
quercetin
signaling pathways
clinical studies
Online Access:https://doi.org/10.1002/ame2.12551
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Summary:Abstract Background Neurodegenerative diseases (NDs), including Alzheimer‘s disease, Parkinson‘s disease, and Huntington‘s disease, are complex and challenging due to their intricate pathophysiology and limited treatment options. Methods This review systematically sourced articles related to neurodegenerative diseases, neurodegeneration, quercetin, and clinical studies from primary medical databases, including Scopus, PubMed, and Web of Science. Results Recent studies have included quercetin to impact the cellular and molecular pathways involved in neurodegeneration. Quercetin, a flavonoid abundant in vegetables and fruits, is gaining attention for its antioxidant, anti‐inflammatory, and antiapoptotic properties. It regulates signaling pathways such as nuclear factor‐κB (NF‐κB), sirtuins, and phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt). These pathways are essential for cellular survival, inflammation regulation, and apoptosis. Preclinical and clinical studies have shown that quercetin improves symptoms and pathology in neurodegenerative models, indicating promising outcomes. Conclusions The study explores the potential of incorporating laboratory research into practical medical treatment, focusing on quercetin‘s neuroprotective effects on NDs and its optimal dosage.
ISSN:2576-2095

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