EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITIS
In our research we have investigated the effect of intraperitoneal introduction of silver nanoparticles solution (linear particle size of 10–20 nm) into intact animals and in the simulation of experimental peritonitis. We have evaluated the indices of nonspecific proteinases and their inhibitors in...
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Siberian State Medical University (Tomsk)
2015-04-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/133 |
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| author | D. V. Chegodar A. V. Kubyshkin V. V. Panasenko |
| author_facet | D. V. Chegodar A. V. Kubyshkin V. V. Panasenko |
| author_sort | D. V. Chegodar |
| collection | DOAJ |
| description | In our research we have investigated the effect of intraperitoneal introduction of silver nanoparticles solution (linear particle size of 10–20 nm) into intact animals and in the simulation of experimental peritonitis. We have evaluated the indices of nonspecific proteinases and their inhibitors in blood serum and peritoneum lavage. The intraperitoneal introduction of silver nanoparticles solution to intact animals leads to the minimal reaction of proteinase-inhibitor systems components in blood serum and peritoneum lavage. When modeling inflammatory process in peritoneum cavity by intraperitoneal injection of 10% filtered fecal suspension of rats, application of silver nanoparticles solution is accompanied by decrease in extent of activation of proteinases and preservation of inhibitory potential, both at systemic and local level, which can indicate antiinflammatory effects of nanosilver. |
| format | Article |
| id | doaj-art-4fd8a668aec14903969e9d1a1ee8e0de |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-4fd8a668aec14903969e9d1a1ee8e0de2025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842015-04-01142677410.20538/1682-0363-2015-2-67-74131EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITISD. V. Chegodar0A. V. Kubyshkin1V. V. Panasenko2Crimea State Medical University named after S.I. Georgievsky, SimferopolCrimea State Medical University named after S.I. Georgievsky, SimferopolCenter of hygiene and epidemiology in the Crimea Republic and federal city of Sevastopol, SimferopolIn our research we have investigated the effect of intraperitoneal introduction of silver nanoparticles solution (linear particle size of 10–20 nm) into intact animals and in the simulation of experimental peritonitis. We have evaluated the indices of nonspecific proteinases and their inhibitors in blood serum and peritoneum lavage. The intraperitoneal introduction of silver nanoparticles solution to intact animals leads to the minimal reaction of proteinase-inhibitor systems components in blood serum and peritoneum lavage. When modeling inflammatory process in peritoneum cavity by intraperitoneal injection of 10% filtered fecal suspension of rats, application of silver nanoparticles solution is accompanied by decrease in extent of activation of proteinases and preservation of inhibitory potential, both at systemic and local level, which can indicate antiinflammatory effects of nanosilver.https://bulletin.ssmu.ru/jour/article/view/133proteinasesproteinase inhibitorsinflammation |
| spellingShingle | D. V. Chegodar A. V. Kubyshkin V. V. Panasenko EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITIS Бюллетень сибирской медицины proteinases proteinase inhibitors inflammation |
| title | EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITIS |
| title_full | EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITIS |
| title_fullStr | EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITIS |
| title_full_unstemmed | EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITIS |
| title_short | EFFECT OF SILVER NANOPARTICLES IN EXPERIMENTAL PERITONITIS |
| title_sort | effect of silver nanoparticles in experimental peritonitis |
| topic | proteinases proteinase inhibitors inflammation |
| url | https://bulletin.ssmu.ru/jour/article/view/133 |
| work_keys_str_mv | AT dvchegodar effectofsilvernanoparticlesinexperimentalperitonitis AT avkubyshkin effectofsilvernanoparticlesinexperimentalperitonitis AT vvpanasenko effectofsilvernanoparticlesinexperimentalperitonitis |