12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation
Interleukin-13 and interferon-γ are important effectors of T-helper cells. Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types. 15-lipoxygenase-1 is dramatically elevated in the airways of subjects with asthma. Studies in ani...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/727305 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545430454403072 |
|---|---|
| author | Alexa R. Lindley Margaret Crapster-Pregont Yanjun Liu Douglas A. Kuperman |
| author_facet | Alexa R. Lindley Margaret Crapster-Pregont Yanjun Liu Douglas A. Kuperman |
| author_sort | Alexa R. Lindley |
| collection | DOAJ |
| description | Interleukin-13 and interferon-γ are important effectors of T-helper cells. Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types. 15-lipoxygenase-1 is dramatically elevated in the airways of subjects with asthma. Studies in animals indicate that 15-lipoxygenase-1 contributes to the development of allergic airway inflammation but is protective in some other forms of inflammation. We tested the hypothesis that the ability of interleukin-13 and interferon-γ to counterregulate allergic airway inflammation was potentially mediated by counterregulation of 12/15-lipoxygenase, the mouse ortholog of 15-lipoxygenase-1. The airways of mice were treated with interleukin-13 or interferon-γ one day prior to each of the four allergen exposures. Interleukin-13 augmented and interferon-γ inhibited allergic airway inflammation independently of systemic IgE and mucosal IgA responses but in association with counterregulation of 12/15-lipoxygenase. Interleukin-13 and interferon-γ counterregulate 12/15-lipoxygenase potentially contributing to the effects of these cytokines on allergic airway inflammation. |
| format | Article |
| id | doaj-art-4fcfdcc696274a71b2d1114abdc6972f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4fcfdcc696274a71b2d1114abdc6972f2025-02-03T07:25:47ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/72730572730512/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway InflammationAlexa R. Lindley0Margaret Crapster-Pregont1Yanjun Liu2Douglas A. Kuperman3Allergy-Immunology Division, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAAllergy-Immunology Division, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAAllergy-Immunology Division, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAAllergy-Immunology Division, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USAInterleukin-13 and interferon-γ are important effectors of T-helper cells. Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types. 15-lipoxygenase-1 is dramatically elevated in the airways of subjects with asthma. Studies in animals indicate that 15-lipoxygenase-1 contributes to the development of allergic airway inflammation but is protective in some other forms of inflammation. We tested the hypothesis that the ability of interleukin-13 and interferon-γ to counterregulate allergic airway inflammation was potentially mediated by counterregulation of 12/15-lipoxygenase, the mouse ortholog of 15-lipoxygenase-1. The airways of mice were treated with interleukin-13 or interferon-γ one day prior to each of the four allergen exposures. Interleukin-13 augmented and interferon-γ inhibited allergic airway inflammation independently of systemic IgE and mucosal IgA responses but in association with counterregulation of 12/15-lipoxygenase. Interleukin-13 and interferon-γ counterregulate 12/15-lipoxygenase potentially contributing to the effects of these cytokines on allergic airway inflammation.http://dx.doi.org/10.1155/2010/727305 |
| spellingShingle | Alexa R. Lindley Margaret Crapster-Pregont Yanjun Liu Douglas A. Kuperman 12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation Mediators of Inflammation |
| title | 12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation |
| title_full | 12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation |
| title_fullStr | 12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation |
| title_full_unstemmed | 12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation |
| title_short | 12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation |
| title_sort | 12 15 lipoxygenase is an interleukin 13 and interferon γ counterregulated mediator of allergic airway inflammation |
| url | http://dx.doi.org/10.1155/2010/727305 |
| work_keys_str_mv | AT alexarlindley 1215lipoxygenaseisaninterleukin13andinterferongcounterregulatedmediatorofallergicairwayinflammation AT margaretcrapsterpregont 1215lipoxygenaseisaninterleukin13andinterferongcounterregulatedmediatorofallergicairwayinflammation AT yanjunliu 1215lipoxygenaseisaninterleukin13andinterferongcounterregulatedmediatorofallergicairwayinflammation AT douglasakuperman 1215lipoxygenaseisaninterleukin13andinterferongcounterregulatedmediatorofallergicairwayinflammation |