Applications and perspectives of metastatic colorectal cancer organoids
Currently, colorectal cancer (CRC) is one of the most malignancies in the world, with high rates of morbidity and mortality. More than 50% of patients will eventually develop tumor metastasis, and patients with metastatic colorectal cancer (mCRC) are not sensitive to most drugs, leading to a poorer...
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| Format: | Article |
| Language: | zho |
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Editorial Office of New Medicine
2024-06-01
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| Series: | Yixue xinzhi zazhi |
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| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/uvFxGH32sfMyocMwWwKreuc15LIrbpztfRwVyEnr.pdf |
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| _version_ | 1850131230485381120 |
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| author | CUI Jingwei WANG Mengjie QIN Fuhao WANG Lu FAN Zhimin |
| author_facet | CUI Jingwei WANG Mengjie QIN Fuhao WANG Lu FAN Zhimin |
| author_sort | CUI Jingwei |
| collection | DOAJ |
| description | Currently, colorectal cancer (CRC) is one of the most malignancies in the world, with high rates of morbidity and mortality. More than 50% of patients will eventually develop tumor metastasis, and patients with metastatic colorectal cancer (mCRC) are not sensitive to most drugs, leading to a poorer prognosis for patients. Although studies of mCRC using patient-derived cancer cells and patient-derived xenografts (PDX) are mature, both still have limitations. However, patient-derived organoids (PDO) has the benefits of duplicating the immune circumstance of real tumor in vivo, preserving tumor heterogeneity, short culture cycles and easy preservation. And it has shown great application value in the fundamental study of mCRC, explanation of the mechanism of drug action, development of new drugs and individualized treatment. In order to explain the importance of organoids in mCRC research and offer directions for future research, this paper summarizes the recent studies and difficulties of organoid technology in recent years. |
| format | Article |
| id | doaj-art-4fca98b9f20d445e8369453df83c97ae |
| institution | OA Journals |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2024-06-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-4fca98b9f20d445e8369453df83c97ae2025-08-20T02:32:29ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112024-06-0134669269810.12173/j.issn.1004-5511.2023080386502Applications and perspectives of metastatic colorectal cancer organoidsCUI JingweiWANG MengjieQIN FuhaoWANG LuFAN ZhiminCurrently, colorectal cancer (CRC) is one of the most malignancies in the world, with high rates of morbidity and mortality. More than 50% of patients will eventually develop tumor metastasis, and patients with metastatic colorectal cancer (mCRC) are not sensitive to most drugs, leading to a poorer prognosis for patients. Although studies of mCRC using patient-derived cancer cells and patient-derived xenografts (PDX) are mature, both still have limitations. However, patient-derived organoids (PDO) has the benefits of duplicating the immune circumstance of real tumor in vivo, preserving tumor heterogeneity, short culture cycles and easy preservation. And it has shown great application value in the fundamental study of mCRC, explanation of the mechanism of drug action, development of new drugs and individualized treatment. In order to explain the importance of organoids in mCRC research and offer directions for future research, this paper summarizes the recent studies and difficulties of organoid technology in recent years.https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/uvFxGH32sfMyocMwWwKreuc15LIrbpztfRwVyEnr.pdfmetastatic colorectal cancerorganoidscolorectal cancercolorectal cancer organoidspatient-derived xenograftspatients-derived organoids |
| spellingShingle | CUI Jingwei WANG Mengjie QIN Fuhao WANG Lu FAN Zhimin Applications and perspectives of metastatic colorectal cancer organoids Yixue xinzhi zazhi metastatic colorectal cancer organoids colorectal cancer colorectal cancer organoids patient-derived xenografts patients-derived organoids |
| title | Applications and perspectives of metastatic colorectal cancer organoids |
| title_full | Applications and perspectives of metastatic colorectal cancer organoids |
| title_fullStr | Applications and perspectives of metastatic colorectal cancer organoids |
| title_full_unstemmed | Applications and perspectives of metastatic colorectal cancer organoids |
| title_short | Applications and perspectives of metastatic colorectal cancer organoids |
| title_sort | applications and perspectives of metastatic colorectal cancer organoids |
| topic | metastatic colorectal cancer organoids colorectal cancer colorectal cancer organoids patient-derived xenografts patients-derived organoids |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2406/uvFxGH32sfMyocMwWwKreuc15LIrbpztfRwVyEnr.pdf |
| work_keys_str_mv | AT cuijingwei applicationsandperspectivesofmetastaticcolorectalcancerorganoids AT wangmengjie applicationsandperspectivesofmetastaticcolorectalcancerorganoids AT qinfuhao applicationsandperspectivesofmetastaticcolorectalcancerorganoids AT wanglu applicationsandperspectivesofmetastaticcolorectalcancerorganoids AT fanzhimin applicationsandperspectivesofmetastaticcolorectalcancerorganoids |