NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs
Increasing evidence suggests that the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3) inflammasome participates in cardiovascular diseases. However, its role and activation mechanism during hypertension remains unclear. In this study, we tested the role and...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/6847087 |
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| author | Xin Zhang Siting Hong Shuhan Qi Wenxiu Liu Xiaohui Zhang Zhiyu Shi Wenjia Chen Meng Zhao Xinhua Yin |
| author_facet | Xin Zhang Siting Hong Shuhan Qi Wenxiu Liu Xiaohui Zhang Zhiyu Shi Wenjia Chen Meng Zhao Xinhua Yin |
| author_sort | Xin Zhang |
| collection | DOAJ |
| description | Increasing evidence suggests that the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3) inflammasome participates in cardiovascular diseases. However, its role and activation mechanism during hypertension remains unclear. In this study, we tested the role and mechanism of calcium-sensing receptor (CaSR) in NLRP3 inflammasome activation during hypertension. We observed that the expressions of CaSR and NLRP3 were increased in spontaneous hypertensive rats (SHRs) along with aortic fibrosis. In vascular smooth muscle cells (VSMCs), the activation of NLRP3 inflammasome associated with CaSR and collagen synthesis was induced by angiotensin II (Ang II). Furthermore, inhibition of CaSR and NLRP3 inflammasome attenuated proinflammatory cytokine release, suggesting that CaSR-mediated activation of the NLRP3 inflammasome may be a therapeutic target in aortic dysfunction and vascular inflammatory lesions. |
| format | Article |
| id | doaj-art-4fc4d59293a444b58aa63cd2551ce7bc |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4fc4d59293a444b58aa63cd2551ce7bc2025-08-20T02:05:38ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/68470876847087NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRsXin Zhang0Siting Hong1Shuhan Qi2Wenxiu Liu3Xiaohui Zhang4Zhiyu Shi5Wenjia Chen6Meng Zhao7Xinhua Yin8Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaDepartment of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaDepartment of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaDepartment of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaDepartment of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaDepartment of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaDepartment of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaDepartment of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaDepartment of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, 150001 Heilongjiang, ChinaIncreasing evidence suggests that the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3) inflammasome participates in cardiovascular diseases. However, its role and activation mechanism during hypertension remains unclear. In this study, we tested the role and mechanism of calcium-sensing receptor (CaSR) in NLRP3 inflammasome activation during hypertension. We observed that the expressions of CaSR and NLRP3 were increased in spontaneous hypertensive rats (SHRs) along with aortic fibrosis. In vascular smooth muscle cells (VSMCs), the activation of NLRP3 inflammasome associated with CaSR and collagen synthesis was induced by angiotensin II (Ang II). Furthermore, inhibition of CaSR and NLRP3 inflammasome attenuated proinflammatory cytokine release, suggesting that CaSR-mediated activation of the NLRP3 inflammasome may be a therapeutic target in aortic dysfunction and vascular inflammatory lesions.http://dx.doi.org/10.1155/2019/6847087 |
| spellingShingle | Xin Zhang Siting Hong Shuhan Qi Wenxiu Liu Xiaohui Zhang Zhiyu Shi Wenjia Chen Meng Zhao Xinhua Yin NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs Mediators of Inflammation |
| title | NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs |
| title_full | NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs |
| title_fullStr | NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs |
| title_full_unstemmed | NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs |
| title_short | NLRP3 Inflammasome Is Involved in Calcium-Sensing Receptor-Induced Aortic Remodeling in SHRs |
| title_sort | nlrp3 inflammasome is involved in calcium sensing receptor induced aortic remodeling in shrs |
| url | http://dx.doi.org/10.1155/2019/6847087 |
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