Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS)
Potential biomarkers of cancerous alterations could be selected by profiling a wide range of analytes. For this purpose, analytical platforms enabling detailed analysis of different biological matrices are applied. However, after biomarker selection, it is essential to shorten the analysis time as m...
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Elsevier
2025-02-01
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| Series: | Advances in Sample Preparation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772582024000433 |
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| author | Joanna Bogusiewicz Karol Jaroch Jacek Furtak Marcin Birski Krystyna Soszyńska Anna Majdańska Agata Ryfa Marek Harat Barbara Bojko |
| author_facet | Joanna Bogusiewicz Karol Jaroch Jacek Furtak Marcin Birski Krystyna Soszyńska Anna Majdańska Agata Ryfa Marek Harat Barbara Bojko |
| author_sort | Joanna Bogusiewicz |
| collection | DOAJ |
| description | Potential biomarkers of cancerous alterations could be selected by profiling a wide range of analytes. For this purpose, analytical platforms enabling detailed analysis of different biological matrices are applied. However, after biomarker selection, it is essential to shorten the analysis time as much as possible to speed up the diagnostic process. Therefore, this study aimed to optimize and test the coated blade spray mass spectrometry (CBS-MS) method in analyzing potential biomarkers in brain tumor studies: acylcarnitine. Meningiomas with different mutation statuses in NF2 were studied due to the relation of NF2 mutation with the higher risk of malignant transformation and multiple meningiomas. The application of CBS-MS enabled the determination of acetylcarnitine concentration (AC C2:0) and propionylcarnitine (AC C3:0) in intact tumor tissue. However, it would be necessary to enlarge the study group to confirm the conclusions on the concentration of these analytes in NF2 mutant and wild-type meningiomas. Apart from qualitative analysis, the simultaneous detection of a wide range of acylcarnitines in untargeted analysis was also possible. |
| format | Article |
| id | doaj-art-4fc3f75f993b452b8fe6805818e5a9e5 |
| institution | OA Journals |
| issn | 2772-5820 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Sample Preparation |
| spelling | doaj-art-4fc3f75f993b452b8fe6805818e5a9e52025-08-20T02:01:24ZengElsevierAdvances in Sample Preparation2772-58202025-02-011310014610.1016/j.sampre.2024.100146Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS)Joanna Bogusiewicz0Karol Jaroch1Jacek Furtak2Marcin Birski3Krystyna Soszyńska4Anna Majdańska5Agata Ryfa6Marek Harat7Barbara Bojko8Department of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-089, Bydgoszcz, PolandDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-089, Bydgoszcz, PolandMedical Faculty, Bydgoszcz University of Science and Technology, 85-796, Bydgoszcz, Poland; Department of Neurosurgery, 10th Military Research Hospital and Polyclinic, 85-681, Bydgoszcz, PolandDepartment of Neurosurgery, 10th Military Research Hospital and Polyclinic, 85-681, Bydgoszcz, PolandLaboratory of Clinical Genetics and Molecular Pathology, Department of Medical Analytics, 10th Military Research Hospital and Polyclinic, 85-681, Bydgoszcz, PolandLaboratory of Clinical Genetics and Molecular Pathology, Department of Medical Analytics, 10th Military Research Hospital and Polyclinic, 85-681, Bydgoszcz, PolandLaboratory of Clinical Genetics and Molecular Pathology, Department of Medical Analytics, 10th Military Research Hospital and Polyclinic, 85-681, Bydgoszcz, PolandMedical Faculty, Bydgoszcz University of Science and Technology, 85-796, Bydgoszcz, Poland; Department of Neurosurgery, 10th Military Research Hospital and Polyclinic, 85-681, Bydgoszcz, PolandDepartment of Pharmacodynamics and Molecular Pharmacology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-089, Bydgoszcz, Poland; Corresponding author.Potential biomarkers of cancerous alterations could be selected by profiling a wide range of analytes. For this purpose, analytical platforms enabling detailed analysis of different biological matrices are applied. However, after biomarker selection, it is essential to shorten the analysis time as much as possible to speed up the diagnostic process. Therefore, this study aimed to optimize and test the coated blade spray mass spectrometry (CBS-MS) method in analyzing potential biomarkers in brain tumor studies: acylcarnitine. Meningiomas with different mutation statuses in NF2 were studied due to the relation of NF2 mutation with the higher risk of malignant transformation and multiple meningiomas. The application of CBS-MS enabled the determination of acetylcarnitine concentration (AC C2:0) and propionylcarnitine (AC C3:0) in intact tumor tissue. However, it would be necessary to enlarge the study group to confirm the conclusions on the concentration of these analytes in NF2 mutant and wild-type meningiomas. Apart from qualitative analysis, the simultaneous detection of a wide range of acylcarnitines in untargeted analysis was also possible.http://www.sciencedirect.com/science/article/pii/S2772582024000433AcylcarnitineSolid-phase microextractionBrain tumorMeningiomaCoated blade spray mass spectrometry |
| spellingShingle | Joanna Bogusiewicz Karol Jaroch Jacek Furtak Marcin Birski Krystyna Soszyńska Anna Majdańska Agata Ryfa Marek Harat Barbara Bojko Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS) Advances in Sample Preparation Acylcarnitine Solid-phase microextraction Brain tumor Meningioma Coated blade spray mass spectrometry |
| title | Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS) |
| title_full | Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS) |
| title_fullStr | Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS) |
| title_full_unstemmed | Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS) |
| title_short | Determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry (CBS-MS) |
| title_sort | determination of acylcarnitines in intact brain tumors using coated blade spray mass spectrometry cbs ms |
| topic | Acylcarnitine Solid-phase microextraction Brain tumor Meningioma Coated blade spray mass spectrometry |
| url | http://www.sciencedirect.com/science/article/pii/S2772582024000433 |
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