Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments
Abstract Background Polycystic Ovary Syndrome (PCOS) affects up to 10% of women of reproductive age, characterized by hormonal imbalances and metabolic complications. Environmental factors potentially influence the biochemical expression of this condition. This study aims to examine the impact of ur...
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Nature Portfolio
2025-07-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-025-00985-6 |
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| author | Jalpa Patel Hiral Chaudhary Abhishek Chudasama Jaydeep Panchal Akanksha Trivedi Sonal Panchal Trupti Joshi Rushikesh Joshi |
| author_facet | Jalpa Patel Hiral Chaudhary Abhishek Chudasama Jaydeep Panchal Akanksha Trivedi Sonal Panchal Trupti Joshi Rushikesh Joshi |
| author_sort | Jalpa Patel |
| collection | DOAJ |
| description | Abstract Background Polycystic Ovary Syndrome (PCOS) affects up to 10% of women of reproductive age, characterized by hormonal imbalances and metabolic complications. Environmental factors potentially influence the biochemical expression of this condition. This study aims to examine the impact of urban versus rural environments on metabolite profiles in women with PCOS. Methods Thirty women aged between 18 and 40, diagnosed with PCOS according to the Rotterdam 2003 criteria, were recruited from June 2022 to May 2023, 16 from urban settings and 14 from rural settings. Serum samples were analyzed using liquid chromatography-tandem mass spectrometry. Principal component analysis and orthogonal partial least squares discriminant analysis were performed to identify metabolic patterns and differences between the two groups. Results This study reveals significant differences in metabolite profiles between women with PCOS from various environmental backgrounds. Rural participants exhibit higher levels of lipid-related metabolites, especially Palmitone, indicating specific dietary influences. Urban participants show distinct changes in carbohydrate and nucleotide metabolism pathways, likely due to processed food consumption. Multivariate analyses demonstrate a clear separation between the groups, emphasizing the environmental impact on PCOS expression. Conclusions This research highlights potential environment-related biomarkers for PCOS, emphasizing the importance of developing tailored treatment strategies considering environmental factors. The distinct metabolic profiles observed between urban and rural women provide new insights into the syndrome’s complex mechanisms, indicating that environmental influences play a critical role in its biochemical expression and may affect its clinical manifestations. |
| format | Article |
| id | doaj-art-4fc3f4469df54102b8d92c1df1ec5096 |
| institution | DOAJ |
| issn | 2730-664X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Medicine |
| spelling | doaj-art-4fc3f4469df54102b8d92c1df1ec50962025-08-20T03:04:17ZengNature PortfolioCommunications Medicine2730-664X2025-07-015111410.1038/s43856-025-00985-6Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environmentsJalpa Patel0Hiral Chaudhary1Abhishek Chudasama2Jaydeep Panchal3Akanksha Trivedi4Sonal Panchal5Trupti Joshi6Rushikesh Joshi7Department of Biochemistry and Forensic Science, University School of Sciences, Gujarat UniversityDepartment of Biochemistry and Forensic Science, University School of Sciences, Gujarat UniversityDepartment of Biochemistry and Forensic Science, University School of Sciences, Gujarat UniversityAdvait Theragnostics Pvt LtdAdvait Theragnostics Pvt LtdDr. Nagori’s Institute for Infertility and IVFUrmi HospitalDepartment of Biochemistry and Forensic Science, University School of Sciences, Gujarat UniversityAbstract Background Polycystic Ovary Syndrome (PCOS) affects up to 10% of women of reproductive age, characterized by hormonal imbalances and metabolic complications. Environmental factors potentially influence the biochemical expression of this condition. This study aims to examine the impact of urban versus rural environments on metabolite profiles in women with PCOS. Methods Thirty women aged between 18 and 40, diagnosed with PCOS according to the Rotterdam 2003 criteria, were recruited from June 2022 to May 2023, 16 from urban settings and 14 from rural settings. Serum samples were analyzed using liquid chromatography-tandem mass spectrometry. Principal component analysis and orthogonal partial least squares discriminant analysis were performed to identify metabolic patterns and differences between the two groups. Results This study reveals significant differences in metabolite profiles between women with PCOS from various environmental backgrounds. Rural participants exhibit higher levels of lipid-related metabolites, especially Palmitone, indicating specific dietary influences. Urban participants show distinct changes in carbohydrate and nucleotide metabolism pathways, likely due to processed food consumption. Multivariate analyses demonstrate a clear separation between the groups, emphasizing the environmental impact on PCOS expression. Conclusions This research highlights potential environment-related biomarkers for PCOS, emphasizing the importance of developing tailored treatment strategies considering environmental factors. The distinct metabolic profiles observed between urban and rural women provide new insights into the syndrome’s complex mechanisms, indicating that environmental influences play a critical role in its biochemical expression and may affect its clinical manifestations.https://doi.org/10.1038/s43856-025-00985-6 |
| spellingShingle | Jalpa Patel Hiral Chaudhary Abhishek Chudasama Jaydeep Panchal Akanksha Trivedi Sonal Panchal Trupti Joshi Rushikesh Joshi Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments Communications Medicine |
| title | Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments |
| title_full | Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments |
| title_fullStr | Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments |
| title_full_unstemmed | Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments |
| title_short | Comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments |
| title_sort | comparing the metabolomic landscape of polycystic ovary syndrome within urban and rural environments |
| url | https://doi.org/10.1038/s43856-025-00985-6 |
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