Elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patients
ObjectiveThe risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) remains inadequately defined. Consequently, this study aims to evaluate the predictive value of remnant cholesterol (RC) for assessing CVD risk in RA patients.MethodsPlasma RC levels were measured in 114 RA...
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Frontiers Media S.A.
2024-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1449219/full |
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| author | Ching-Kun Chang Ching-Kun Chang Ching-Kun Chang Ching-Kun Chang Yi-Chen Li Yi-Chen Li Yi-Chen Li Po-Ku Chen Po-Ku Chen Po-Ku Chen Shih-Hsin Chang Shih-Hsin Chang Shih-Hsin Chang Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen |
| author_facet | Ching-Kun Chang Ching-Kun Chang Ching-Kun Chang Ching-Kun Chang Yi-Chen Li Yi-Chen Li Yi-Chen Li Po-Ku Chen Po-Ku Chen Po-Ku Chen Shih-Hsin Chang Shih-Hsin Chang Shih-Hsin Chang Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen |
| author_sort | Ching-Kun Chang |
| collection | DOAJ |
| description | ObjectiveThe risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) remains inadequately defined. Consequently, this study aims to evaluate the predictive value of remnant cholesterol (RC) for assessing CVD risk in RA patients.MethodsPlasma RC levels were measured in 114 RA patients and 41 healthy controls, calculated as total cholesterol minus HDL-C and LDL-C. These levels were further analyzed using 1H-NMR lipid/metabolomics. Meanwhile, the 28-joint Disease Activity Score (DAS28) assessed RA activity.ResultsRC levels were significantly elevated in RA patients (19.0 mg/dl, p < 0.001) compared to healthy controls (14.5 mg/dl). Furthermore, RC levels were significantly elevated at 37.4 mg/dl in patients who experienced cardiovascular event (CVE) compared to 17.4 mg/dl in those without CVE (p < 0.001). To enhance the precision and reliability of RC measurements, RC concentrations were further validated using 1H-NMR spectroscopy. Additionally, a positive correlation was observed between RC levels and DAS28. Multivariate analysis identified RC as a significant predictor of CVE (odds ratio = 1.82, p = 0.013). ROC curve analysis revealed superior predictive capability of RC for CVE (AUC = 0.919, p < 0.001) compared to LDL-C (AUC = 0.669, p = 0.018), with a high sensitivity of 94.7% and a specificity of 82.1%.ConclusionElevated RC levels demonstrate greater accuracy in predicting CVE occurrence in RA patients compared to traditional measures such as LDL-C. These findings suggest that elevated RC levels may serve as a novel predictor for occurrence of CVE in RA patients, facilitating early intervention strategies based on the risk stratification. |
| format | Article |
| id | doaj-art-4fbc3d201cdd4f419336cd0b35d7518a |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-4fbc3d201cdd4f419336cd0b35d7518a2025-08-20T01:55:12ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-09-011110.3389/fcvm.2024.14492191449219Elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patientsChing-Kun Chang0Ching-Kun Chang1Ching-Kun Chang2Ching-Kun Chang3Yi-Chen Li4Yi-Chen Li5Yi-Chen Li6Po-Ku Chen7Po-Ku Chen8Po-Ku Chen9Shih-Hsin Chang10Shih-Hsin Chang11Shih-Hsin Chang12Der-Yuan Chen13Der-Yuan Chen14Der-Yuan Chen15Der-Yuan Chen16Rheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanCollege of Medicine, China Medical University, Taichung, TaiwanTranslational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanOrgan-on-a Chip Fabrication and Verification Division, Taiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu, TaiwanClinical Medicine Research Center, National Cheng Kung University Hospital, Tainan, TaiwanCenter of Cell Therapy, National Cheng Kung University Hospital, Tainan, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanRheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanCollege of Medicine, China Medical University, Taichung, TaiwanTranslational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanRheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanCollege of Medicine, China Medical University, Taichung, TaiwanTranslational Medicine and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, TaiwanRheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanCollege of Medicine, China Medical University, Taichung, TaiwanTranslational Medicine Laboratory, Rheumatology and Immunology Center, China Medical University Hospital, Taichung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, TaiwanObjectiveThe risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) remains inadequately defined. Consequently, this study aims to evaluate the predictive value of remnant cholesterol (RC) for assessing CVD risk in RA patients.MethodsPlasma RC levels were measured in 114 RA patients and 41 healthy controls, calculated as total cholesterol minus HDL-C and LDL-C. These levels were further analyzed using 1H-NMR lipid/metabolomics. Meanwhile, the 28-joint Disease Activity Score (DAS28) assessed RA activity.ResultsRC levels were significantly elevated in RA patients (19.0 mg/dl, p < 0.001) compared to healthy controls (14.5 mg/dl). Furthermore, RC levels were significantly elevated at 37.4 mg/dl in patients who experienced cardiovascular event (CVE) compared to 17.4 mg/dl in those without CVE (p < 0.001). To enhance the precision and reliability of RC measurements, RC concentrations were further validated using 1H-NMR spectroscopy. Additionally, a positive correlation was observed between RC levels and DAS28. Multivariate analysis identified RC as a significant predictor of CVE (odds ratio = 1.82, p = 0.013). ROC curve analysis revealed superior predictive capability of RC for CVE (AUC = 0.919, p < 0.001) compared to LDL-C (AUC = 0.669, p = 0.018), with a high sensitivity of 94.7% and a specificity of 82.1%.ConclusionElevated RC levels demonstrate greater accuracy in predicting CVE occurrence in RA patients compared to traditional measures such as LDL-C. These findings suggest that elevated RC levels may serve as a novel predictor for occurrence of CVE in RA patients, facilitating early intervention strategies based on the risk stratification.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1449219/fullremnant cholesterol (RC)low-density lipoprotein (LDL)predictioncardiovascular events (CVE)rheumatoid arthritis (RA) |
| spellingShingle | Ching-Kun Chang Ching-Kun Chang Ching-Kun Chang Ching-Kun Chang Yi-Chen Li Yi-Chen Li Yi-Chen Li Po-Ku Chen Po-Ku Chen Po-Ku Chen Shih-Hsin Chang Shih-Hsin Chang Shih-Hsin Chang Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen Der-Yuan Chen Elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patients Frontiers in Cardiovascular Medicine remnant cholesterol (RC) low-density lipoprotein (LDL) prediction cardiovascular events (CVE) rheumatoid arthritis (RA) |
| title | Elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patients |
| title_full | Elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patients |
| title_fullStr | Elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patients |
| title_full_unstemmed | Elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patients |
| title_short | Elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patients |
| title_sort | elevated remnant cholesterol as a potential predictor for cardiovascular events in rheumatoid arthritis patients |
| topic | remnant cholesterol (RC) low-density lipoprotein (LDL) prediction cardiovascular events (CVE) rheumatoid arthritis (RA) |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1449219/full |
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