Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells.
Tissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells' biology. However, very little is known about whether the tissue re...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0223397&type=printable |
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| author | Qingtai Su Aurélie Bouteau Jacob Cardenas Balaji Uthra Yuanyaun Wang Cynthia Smitherman Jinghua Gu Botond Z Igyártó |
| author_facet | Qingtai Su Aurélie Bouteau Jacob Cardenas Balaji Uthra Yuanyaun Wang Cynthia Smitherman Jinghua Gu Botond Z Igyártó |
| author_sort | Qingtai Su |
| collection | DOAJ |
| description | Tissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells' biology. However, very little is known about whether the tissue resident immune cells in return also affect the local environment. In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells. Thus, immune cells might play an active role in maintaining tissue homeostasis, which should be taken in consideration at data interpretation. |
| format | Article |
| id | doaj-art-4fbb904bdc774c01a9670e235f6e6915 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4fbb904bdc774c01a9670e235f6e69152025-08-20T02:00:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01151e022339710.1371/journal.pone.0223397Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells.Qingtai SuAurélie BouteauJacob CardenasBalaji UthraYuanyaun WangCynthia SmithermanJinghua GuBotond Z IgyártóTissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells' biology. However, very little is known about whether the tissue resident immune cells in return also affect the local environment. In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells. Thus, immune cells might play an active role in maintaining tissue homeostasis, which should be taken in consideration at data interpretation.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0223397&type=printable |
| spellingShingle | Qingtai Su Aurélie Bouteau Jacob Cardenas Balaji Uthra Yuanyaun Wang Cynthia Smitherman Jinghua Gu Botond Z Igyártó Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells. PLoS ONE |
| title | Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells. |
| title_full | Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells. |
| title_fullStr | Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells. |
| title_full_unstemmed | Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells. |
| title_short | Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells. |
| title_sort | brief communication long term absence of langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal t cells |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0223397&type=printable |
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