The role of tranexamic acid use in primary anterior cruciate ligament reconstruction; a prospective comparison
Background: The purpose of this study was to evaluate the effects of tranexamic acid (TXA) in anterior cruciate ligament reconstruction (ACLR) with a focus on bleeding, hemarthrosis, postoperative pain, and early rehabilitation outcomes.Objectives: This study was conducted to investigate whether the...
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Kashan University of Medical Sciences
2025-03-01
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| Series: | Archives of Trauma Research |
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| Online Access: | https://archtrauma.kaums.ac.ir/article_214576_4e39d5cf5069569412aa2c433b69dba4.pdf |
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| author | Murat Yuncu Ozkan Kose Faruk Aykanat Omer Egerci Fırat Dogruoz Aliekber Yapar |
| author_facet | Murat Yuncu Ozkan Kose Faruk Aykanat Omer Egerci Fırat Dogruoz Aliekber Yapar |
| author_sort | Murat Yuncu |
| collection | DOAJ |
| description | Background: The purpose of this study was to evaluate the effects of tranexamic acid (TXA) in anterior cruciate ligament reconstruction (ACLR) with a focus on bleeding, hemarthrosis, postoperative pain, and early rehabilitation outcomes.Objectives: This study was conducted to investigate whether the use of TXA in ACLR can significantly reduce intraoperative and postoperative bleeding while improving pain management and functional recovery in the early postoperative period.Methods: This prospective, non-randomized observational study included 103 patients undergoing ACLR. Fifty-two patients received intravenous TXA (15 mg/kg) 15 minutes before tourniquet inflation, while 51 patients received no medication. Estimated blood loss, drain output, thigh circumference increase, pain on the first postoperative day, additional analgesic requirements, hospital stay length, and functional outcomes at 8 weeks were compared between groups.Results: The TXA group demonstrated significantly lower drain output (p = 0.001), thigh circumference increment (p = 0.001), and estimated blood loss (p = 0.001) compared to the control group. However, no significant differences were observed in postoperative pain (p = 0.807), additional analgesic requirements (p = 0.386), hospital stay length (p = 0.062), or functional outcomes at 8 weeks (p = 0.397). None of the patients required blood transfusion or knee aspiration for hemarthrosis.Conclusions: Although TXA reduces bleeding parameters during ACLR, it does not significantly impact postoperative pain or functional recovery. Its clinical benefit appears limited to reducing bleeding without altering overall postoperative management. |
| format | Article |
| id | doaj-art-4fb5ba0de0224ea2b8b90ba48c7e357d |
| institution | OA Journals |
| issn | 2251-953X 2251-9599 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Kashan University of Medical Sciences |
| record_format | Article |
| series | Archives of Trauma Research |
| spelling | doaj-art-4fb5ba0de0224ea2b8b90ba48c7e357d2025-08-20T02:30:27ZengKashan University of Medical SciencesArchives of Trauma Research2251-953X2251-95992025-03-011411810.48307/atr.2025.449750.1104214576The role of tranexamic acid use in primary anterior cruciate ligament reconstruction; a prospective comparisonMurat Yuncu0Ozkan Kose1Faruk Aykanat2Omer Egerci3Fırat Dogruoz4Aliekber Yapar5Antalya Training and Research Hospital, Department of Orthopedics and Traumatology, Antalya, TurkeyAntalya Training and Research Hospital, Department of Orthopedics and Traumatology, Antalya, TurkeySanko University, Vocational School of Health Services, Gaziantep, TurkeyAntalya Training and Research Hospital, Department of Orthopedics and Traumatology, Antalya, TurkeyAntalya Training and Research Hospital, Department of Orthopedics and Traumatology, Antalya, TurkeyAntalya Training and Research Hospital, Department of Orthopedics and Traumatology, Antalya, TurkeyBackground: The purpose of this study was to evaluate the effects of tranexamic acid (TXA) in anterior cruciate ligament reconstruction (ACLR) with a focus on bleeding, hemarthrosis, postoperative pain, and early rehabilitation outcomes.Objectives: This study was conducted to investigate whether the use of TXA in ACLR can significantly reduce intraoperative and postoperative bleeding while improving pain management and functional recovery in the early postoperative period.Methods: This prospective, non-randomized observational study included 103 patients undergoing ACLR. Fifty-two patients received intravenous TXA (15 mg/kg) 15 minutes before tourniquet inflation, while 51 patients received no medication. Estimated blood loss, drain output, thigh circumference increase, pain on the first postoperative day, additional analgesic requirements, hospital stay length, and functional outcomes at 8 weeks were compared between groups.Results: The TXA group demonstrated significantly lower drain output (p = 0.001), thigh circumference increment (p = 0.001), and estimated blood loss (p = 0.001) compared to the control group. However, no significant differences were observed in postoperative pain (p = 0.807), additional analgesic requirements (p = 0.386), hospital stay length (p = 0.062), or functional outcomes at 8 weeks (p = 0.397). None of the patients required blood transfusion or knee aspiration for hemarthrosis.Conclusions: Although TXA reduces bleeding parameters during ACLR, it does not significantly impact postoperative pain or functional recovery. Its clinical benefit appears limited to reducing bleeding without altering overall postoperative management.https://archtrauma.kaums.ac.ir/article_214576_4e39d5cf5069569412aa2c433b69dba4.pdftranexamic acidanterior cruciate ligamentreconstructionhemarthrosisbleeding |
| spellingShingle | Murat Yuncu Ozkan Kose Faruk Aykanat Omer Egerci Fırat Dogruoz Aliekber Yapar The role of tranexamic acid use in primary anterior cruciate ligament reconstruction; a prospective comparison Archives of Trauma Research tranexamic acid anterior cruciate ligament reconstruction hemarthrosis bleeding |
| title | The role of tranexamic acid use in primary anterior cruciate ligament reconstruction; a prospective comparison |
| title_full | The role of tranexamic acid use in primary anterior cruciate ligament reconstruction; a prospective comparison |
| title_fullStr | The role of tranexamic acid use in primary anterior cruciate ligament reconstruction; a prospective comparison |
| title_full_unstemmed | The role of tranexamic acid use in primary anterior cruciate ligament reconstruction; a prospective comparison |
| title_short | The role of tranexamic acid use in primary anterior cruciate ligament reconstruction; a prospective comparison |
| title_sort | role of tranexamic acid use in primary anterior cruciate ligament reconstruction a prospective comparison |
| topic | tranexamic acid anterior cruciate ligament reconstruction hemarthrosis bleeding |
| url | https://archtrauma.kaums.ac.ir/article_214576_4e39d5cf5069569412aa2c433b69dba4.pdf |
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