Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment
Abstract. Background. Drug-coated balloons (DCBs) are an up-and-coming tactic in treating in-stent restenosis and coronary artery small vessel disease, but their efficacy in treating acute myocardial infarction needs to be further explored. Methods. A meta-analysis of 7 studies was conducted to make...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2022-12-01
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| Series: | Emergency and Critical Care Medicine |
| Online Access: | http://journals.lww.com/10.1097/EC9.0000000000000050 |
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| author | Jing Yang Shuting Chang Jing Liu Guanzhao Zhang Yue Wang Baixue Zhang Zifan Nie Yuanbao Dong Bo Li |
| author_facet | Jing Yang Shuting Chang Jing Liu Guanzhao Zhang Yue Wang Baixue Zhang Zifan Nie Yuanbao Dong Bo Li |
| author_sort | Jing Yang |
| collection | DOAJ |
| description | Abstract. Background. Drug-coated balloons (DCBs) are an up-and-coming tactic in treating in-stent restenosis and coronary artery small vessel disease, but their efficacy in treating acute myocardial infarction needs to be further explored.
Methods. A meta-analysis of 7 studies was conducted to make a comparison with the results of DCB and drug-eluting stent implantation after a median follow-up of 15 months.
Results. A total of 922 patients were included in this analysis in total, including 375 patients in the DCB group and 547 patients in the stent group. A total of 962 vascular diseases were manifested in the 2 groups. After 6 to 24 months of follow-up, there was no statistically significant difference with respect to major adverse cardiovascular events (odds ratio [OR]: 0.82; 95% confidence interval [CI]: 0.52–1.29; Z = 0.85; P = 0.39), cardiac death (OR: 0.92; 95% CI: 0.39–2.12; Z = 0.21; P = 0.84), target lesion revascularization (OR: 1.09; 95% CI: 0.53–2.25; Z = 0.24; P = 0.81), late lumen loss (MD: −0.05; 95% CI: −0.15 to 0.06; Z = 0.85; P = 0.40), or dual antiplatelet therapy (DAPT) (OR: 1.04; 95% CI: 0.53–2.05; Z = 0.11; P = 0.91) between the 2 groups. In the DCB group, persistent residual stenosis or C-F dissection occurrence necessitated that a total of 30 patients receive extra bailout implantations. The rate of bailout stenting was 11.8% (95% CI: 7.1–16). Moreover, the DCB group had a shorter DAPT duration compared with the stent group.
Conclusion. Drug-coated balloons with shorter DAPT durations may be as effective and safe as stent therapy in treating acute myocardial infarction. |
| format | Article |
| id | doaj-art-4fb4a40b6b5b43039f4f134f72f3a33d |
| institution | OA Journals |
| issn | 2097-0617 2693-860X |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Emergency and Critical Care Medicine |
| spelling | doaj-art-4fb4a40b6b5b43039f4f134f72f3a33d2025-08-20T02:26:10ZengWolters Kluwer Health/LWWEmergency and Critical Care Medicine2097-06172693-860X2022-12-012422523210.1097/EC9.0000000000000050202212000-00009Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatmentJing Yang0Shuting Chang1Jing Liu2Guanzhao Zhang3Yue Wang4Baixue Zhang5Zifan Nie6Yuanbao Dong7Bo Li8a Binzhou Medical University, Yantai, Shandong, Chinab Department of Cardiology, Shandong University Zibo Central Hospital, Zibo, Shandong, Chinae Department of Intravenous Drug Dispensing, Shandong University Zibo Central Hospital, Zibo, Shandong, Chinaa Binzhou Medical University, Yantai, Shandong, Chinab Department of Cardiology, Shandong University Zibo Central Hospital, Zibo, Shandong, Chinab Department of Cardiology, Shandong University Zibo Central Hospital, Zibo, Shandong, Chinaa Binzhou Medical University, Yantai, Shandong, Chinag Weifang Fangzi District People’s Hospital, Weifang, Shandong, China.b Department of Cardiology, Shandong University Zibo Central Hospital, Zibo, Shandong, ChinaAbstract. Background. Drug-coated balloons (DCBs) are an up-and-coming tactic in treating in-stent restenosis and coronary artery small vessel disease, but their efficacy in treating acute myocardial infarction needs to be further explored. Methods. A meta-analysis of 7 studies was conducted to make a comparison with the results of DCB and drug-eluting stent implantation after a median follow-up of 15 months. Results. A total of 922 patients were included in this analysis in total, including 375 patients in the DCB group and 547 patients in the stent group. A total of 962 vascular diseases were manifested in the 2 groups. After 6 to 24 months of follow-up, there was no statistically significant difference with respect to major adverse cardiovascular events (odds ratio [OR]: 0.82; 95% confidence interval [CI]: 0.52–1.29; Z = 0.85; P = 0.39), cardiac death (OR: 0.92; 95% CI: 0.39–2.12; Z = 0.21; P = 0.84), target lesion revascularization (OR: 1.09; 95% CI: 0.53–2.25; Z = 0.24; P = 0.81), late lumen loss (MD: −0.05; 95% CI: −0.15 to 0.06; Z = 0.85; P = 0.40), or dual antiplatelet therapy (DAPT) (OR: 1.04; 95% CI: 0.53–2.05; Z = 0.11; P = 0.91) between the 2 groups. In the DCB group, persistent residual stenosis or C-F dissection occurrence necessitated that a total of 30 patients receive extra bailout implantations. The rate of bailout stenting was 11.8% (95% CI: 7.1–16). Moreover, the DCB group had a shorter DAPT duration compared with the stent group. Conclusion. Drug-coated balloons with shorter DAPT durations may be as effective and safe as stent therapy in treating acute myocardial infarction.http://journals.lww.com/10.1097/EC9.0000000000000050 |
| spellingShingle | Jing Yang Shuting Chang Jing Liu Guanzhao Zhang Yue Wang Baixue Zhang Zifan Nie Yuanbao Dong Bo Li Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment Emergency and Critical Care Medicine |
| title | Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment |
| title_full | Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment |
| title_fullStr | Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment |
| title_full_unstemmed | Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment |
| title_short | Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment |
| title_sort | drug coated balloons are not inferior to drug coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment |
| url | http://journals.lww.com/10.1097/EC9.0000000000000050 |
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